NELF-E Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol, a potent CDK inhibitor, hinders the phosphorylation of RNA Pol II, thereby impeding the release of NELF-E from the transcription elongation complex. This interruption leads to transcriptional pausing and the inhibition of mRNA synthesis. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is a selective inhibitor of transcription elongation, acting by preventing the transition of RNA Pol II from the initiation to the elongation phase. By impeding this process, DRB indirectly inhibits NELF-E function, contributing to the regulation of gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D, a DNA-intercalating agent, disrupts transcription by inhibiting RNA Pol II. This disruption leads to the downregulation of NELF-E activity by preventing its association with the transcriptional machinery, consequently influencing the transcriptional pausing of RNA Pol II. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin is a potent inhibitor of RNA Pol II, leading to the blockade of mRNA synthesis. By disrupting the normal progression of transcription, α-Amanitin indirectly affects NELF-E by impeding its involvement in the regulation of RNA Pol II elongation, thereby influencing gene expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits RNA Pol II transcription by interfering with the formation of the initiation complex. This disruption prevents the recruitment of NELF-E to the transcription elongation complex, subsequently impacting the modulation of gene expression by controlling RNA Pol II elongation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid, inhibits CDK9, a component of the P-TEFb complex. By interfering with CDK9 activity, quercetin indirectly influences NELF-E function, preventing its dissociation from the transcription elongation complex and contributing to the regulation of RNA Pol II elongation. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, an antibiotic targeting bacterial RNA Pol, also inhibits eukaryotic RNA Pol II. By disrupting transcription elongation, rifampicin indirectly affects NELF-E function, influencing its role in the regulation of RNA Pol II elongation and gene expression. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
CX-5461 inhibits RNA Pol I, leading to the disruption of ribosomal RNA synthesis. This disruption indirectly affects NELF-E by modulating the availability of ribosomal RNA, potentially influencing its role in the regulation of transcriptional pausing and RNA Pol II elongation. | ||||||