NELF-D Inhibitors
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the transcriptional activity of RNA polymerase II, thereby indirectly affecting the function of NELFCD, which is part of the NELF complex that regulates RNA polymerase II activity. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is a potent inhibitor of the positive transcription elongation factor b (P-TEFb), which phosphorylates RNA polymerase II and counteracts the negative effects of NELF. By inhibiting P-TEFb, DRB can indirectly increase NELFCD-mediated transcriptional pause. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits CDK9, a component of P-TEFb, leading to reduced phosphorylation of RNA polymerase II and increased transcriptional pausing, where NELFCD is involved. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Alpha-amanitin binds to and inhibits RNA polymerase II. This binding leads to an indirect effect on NELFCD as it disrupts the elongation phase of transcription where NELFCD functions. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
I-BET151 is a BET bromodomain inhibitor that displaces BET proteins from chromatin, affecting transcription regulation and potentially increasing the influence of NELFCD on transcriptional pausing. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is another BET bromodomain inhibitor that competes with acetyl-lysine recognition motifs on histones, which could indirectly enhance the activity of NELFCD in transcriptional pausing by altering chromatin structure. | ||||||
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $299.00 $5699.00 $11099.00 $25500.00 $66300.00 $2875.00 | 63 | |
Pladienolide B binds to the spliceosome, potentially influencing post-transcriptional modifications and the transcription elongation process where NELFCD is active. | ||||||
5-Chloro-2-methyl-4-isothiazolin-3-one (CMI/MI > 2.0) | 26172-55-4 | sc-352647 sc-352647A sc-352647B | 5 g 25 g 100 g | $94.00 $206.00 $501.00 | 5 | |
Isothiazolones like this one can inhibit various transcription factors and may indirectly affect transcription elongation and pausing involving NELFCD. Specific CAS numbers are not available as this refers to a class of compounds. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Hesperadin inhibits Aurora B kinase, which can indirectly affect transcription regulation and elongation processes involving NELFCD. | ||||||
2-Indolone | 59-48-3 | sc-220742 | 5 g | $205.00 | ||
Oxindole inhibits CDKs and could indirectly impact transcription elongation and the activity of NELFCD within the NELF complex. | ||||||