Molecular structure of 2-Indolone, CAS Number: 59-48-3
2-Indolone (CAS 59-48-3)
Alternate Names:
Oxindole; 2-Indolinone
Application:
2-Indolone is an indole analogue, that shows pharmacological activity.
CAS Number:
59-48-3
Molecular Weight:
133.15
Molecular Formula:
C8H7NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2-Indolone is an indole analogue, that shows pharmacological activity.
2-Indolone (CAS 59-48-3) References
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- A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. | Lane, ME., et al. 2001. Cancer Res. 61: 6170-7. PMID: 11507069
- Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis. | Bramson, HN., et al. 2001. J Med Chem. 44: 4339-58. PMID: 11728181
- SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. | Yu, B., et al. 2002. Biochem Pharmacol. 64: 1091-100. PMID: 12234612
- 2-Indolinone a versatile scaffold for treatment of cancer: a patent review (2008-2014). | Leoni, A., et al. 2016. Expert Opin Ther Pat. 26: 149-73. PMID: 26561198
- Oxindole: A chemical prism carrying plethora of therapeutic benefits. | Kaur, M., et al. 2016. Eur J Med Chem. 123: 858-894. PMID: 27543880
- Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances. | Dhokne, P., et al. 2021. Eur J Med Chem. 216: 113334. PMID: 33721669
- Oxindole and its derivatives: A review on recent progress in biological activities. | Khetmalis, YM., et al. 2021. Biomed Pharmacother. 141: 111842. PMID: 34174506
- Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. | Mohammadi, M., et al. 1997. Science. 276: 955-60. PMID: 9139660
- Estimation of partition coefficients by MEKC Part I: Potential pharmaceuticals based on 2‐quinolone and 2‐indolone | Gavenda, A., Bednář, P., Barták, P., Adamovský, P., Ševčík, J., Tzoumas, P., & Ulrichová, J. 2001. Journal of separation science. 24(9): 723-728.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Indolone, 5 g | sc-220742 | 5 g | $205.00 |