Nek6 Activators
Nek6 activators encompass a diverse array of chemical compounds that enhance the kinase function of Nek6 through varying modes of action within cellular signaling networks. For instance, Staurosporine indirectly promotes Nek6 activity by inhibiting other kinases that might otherwise phosphorylate substrates of Nek6, effectively reducing the competition for those substrates and allowing Nek6 to function more effectively. Meanwhile, Forskolin's role in amplifying cAMP levels leads to the activation of Protein Kinase A (PKA), which can phosphorylate and thus activate Nek6 as a consequence of the cAMP-dependent signaling cascade's upregulation. Okadaic Acid's inhibition of protein phosphatases PP1 and PP2A results in sustained phosphorylation, and consequently, enhanced activity of Nek6 since phosphorylation is a common regulatory mechanism for kinase activation.
Further supporting the activity of Nek6, Pervanadate's inhibition of tyrosine phosphatases can result in increased tyrosine phosphorylation of various proteins, thereby potentially creating a favorable context for Nek6 activation. The proteasome inhibitor MG132 can lead to an accumulation of regulatory proteins, which indirectly can perturb cellular signaling networks in a manner that favors Nek6 activation. The induction of oxidative stress by Sodium Arsenite may activate stress-responsive kinases, including Nek6, as part of a broader cellular response to oxidative damage.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, which can nonspecifically enhance the activity of Nek6 by inhibiting competing kinases, thereby indirectly upregulating Nek6 pathway signaling due to reduced dephosphorylation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP can lead to the activation of PKA, which can phosphorylate and enhance the activity of Nek6 as part of the cAMP-dependent signaling cascade. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a phosphatase inhibitor that targets PP1 and PP2A, potentially leading to increased phosphorylation and thus activation of Nek6 by reducing its dephosphorylation. | ||||||
Sodium hexafluorosilicate | 16893-85-9 | sc-253583 sc-253583A | 100 g 500 g | $20.00 $39.00 | ||
Pervanadate is a general inhibitor of tyrosine phosphatases, which may lead to enhanced tyrosine phosphorylation of proteins that can indirectly activate Nek6 through downstream signaling effects. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of proteins within the cell, possibly altering signaling pathways and indirectly enhancing the activity of Nek6 through stress responses. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $106.00 $765.00 | 3 | |
Sodium arsenite induces oxidative stress, which can lead to the activation of stress-responsive kinases that enhance the activity of Nek6 as part of the cellular stress response. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is a selective proteasome inhibitor that may cause the buildup of regulatory proteins, which can indirectly increase the activity of Nek6 through stress response signaling pathways. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A is a phosphatase inhibitor that, like okadaic acid, can lead to increased phosphorylation and activity of Nek6 by preventing dephosphorylation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can alter AKT signaling, potentially leading to compensatory mechanisms that enhance the activity of Nek6 as part of the PI3K/AKT pathway adjustments. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib is a kinase inhibitor with targets including RAF, which may lead to altered signaling dynamics upstream of Nek6, potentially enhancing its functional activity due to pathway compensation. | ||||||