Nek2 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SU 9516 | 377090-84-1 | sc-222330 sc-222330A | 5 mg 25 mg | $124.00 $391.00 | 3 | |
SU9516 is a cyclin-dependent kinase inhibitor, which by affecting CDK2, can indirectly modulate Nek2 activity. Since Nek2 is involved in centrosome separation, which is tightly coordinated with the cell cycle, inhibition of CDK2 leads to cell cycle arrest, thereby affecting Nek2's role in mitosis. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A, a selective CDK inhibitor, particularly targeting CDK1, CDK2, and CDK5, can indirectly lead to the inhibition of Nek2 by disrupting the cell cycle progression and consequently mitotic processes where Nek2 is key. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $247.00 $888.00 | 1 | |
Targeting multiple CDKs, dinaciclib can impair cell cycle progression, influencing the activation of Nek2, as its kinase activity is cell cycle-dependent, peaking in the G2/M phase. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a potent and selective inhibitor of CDKs 2, 7 and 9. It affects transcription and cell cycle regulation, which can impact the regulation and function of Nek2 indirectly. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
Tozasertib is an Aurora kinase inhibitor. Since Aurora A kinase can phosphorylate Nek2, its inhibition can reduce Nek2 activity indirectly by preventing its phosphorylation and activation. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib, an inhibitor of Aurora A kinase, can affect Nek2 indirectly by altering the phosphorylation state of proteins that are involved in centrosome duplication and separation, processes regulated by Nek2. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
As a selective inhibitor of the kinesin Eg5, S-trityl-L-cysteine disrupts mitotic spindle formation. Since Nek2 regulates centrosomal cohesion, disrupting spindle dynamics can indirectly affect Nek2's functional role. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor, with activity against both Aurora A and B. Inhibition of these kinases can disturb the phosphorylation state of proteins associated with Nek2 function. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Hesperadin inhibits Aurora B kinase, which is involved in chromosome alignment and segregation, processes that are also regulated by Nek2, suggesting an indirect inhibition. | ||||||
AZ 3146 | 1124329-14-1 | sc-361114 sc-361114A | 10 mg 50 mg | $218.00 $905.00 | 7 | |
AZ3146 is a selective inhibitor of the mitotic checkpoint kinase Mps1, which is essential for the spindle assembly checkpoint, a process where Nek2 also has a role. | ||||||