Date published: 2026-5-6

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NDUFS1 Inhibitors

NDUFS1 inhibitors comprise a diverse collection of compounds that have been methodically designed to modulate the activity of NDUFS1 (NADH:Ubiquinone Oxidoreductase Core Subunit S1), a crucial component of Complex I in the mitochondrial electron transport chain. These inhibitors are meticulously developed through an intricate interplay of molecular insights and mechanistic understanding, often utilizing advanced techniques such as computational modeling, high-throughput screening, and chemical synthesis. The primary objective is to engineer compounds with precision to selectively target NDUFS1, potentially influencing its role in electron transfer and energy production. By targeting NDUFS1, these inhibitors offer valuable tools for unraveling the intricate mechanisms that govern mitochondrial function and cellular energetics, shedding light on the nuanced dynamics that underlie efficient ATP generation and cellular metabolism. The exploration of NDUFS1 inhibitors contributes to a deeper understanding of the finely orchestrated interactions within the electron transport chain, providing insights into the molecular orchestration that supports cellular bioenergetics and mitochondrial physiology.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$259.00
41
(2)

An experimental compound, rotenone is a well-known inhibitor of Complex I, including NDUFS1, leading to disruption of electron transport and energy production.

Piericidin A

2738-64-9sc-202287
2 mg
$291.00
24
(1)

This natural product inhibits Complex I, including NDUFS1, by disrupting electron transfer within the mitochondrial respiratory chain.

Acephate

30560-19-1sc-203800
50 mg
$61.00
(1)

An insecticide, acephate has been studied for its inhibitory effects on Complex I, which includes NDUFS1, in certain insect species.

Myxothiazol

76706-55-3sc-507550
1 mg
$148.00
(0)

This compound inhibits Complex I by binding to its quinone-binding site, which impacts electron transfer involving NDUFS1.

Methoxyacetic acid

625-45-6sc-250319
50 g
$29.00
(0)

An experimental compound, methoxyacetic acid has been explored for its potential inhibitory effects on Complex I, including NDUFS1.

Guazatine acetate salt

115044-19-4sc-224010
100 mg
$136.00
(1)

This fungicide has been studied for its potential inhibitory effects on Complex I, which includes NDUFS1, in fungal mitochondria.

Isopyrazam

881685-58-1sc-488943
100 mg
$194.00
(0)

An agricultural fungicide, isopyrazam has been investigated for its inhibitory effects on Complex I, potentially impacting NDUFS1-mediated electron transport.

Niclosamide

50-65-7sc-250564
sc-250564A
sc-250564B
sc-250564C
sc-250564D
sc-250564E
100 mg
1 g
10 g
100 g
1 kg
5 kg
$38.00
$79.00
$188.00
$520.00
$1248.00
$5930.00
8
(1)

This antiparasitic drug has been studied for its potential inhibitory effects on Complex I, which includes NDUFS1, in parasites.

1,1-Dimethylbiguanide, Hydrochloride

1115-70-4sc-202000F
sc-202000A
sc-202000B
sc-202000C
sc-202000D
sc-202000E
sc-202000
10 mg
5 g
10 g
50 g
100 g
250 g
1 g
$20.00
$43.00
$63.00
$156.00
$260.00
$510.00
$31.00
37
(1)

An approved agent in research for type 2 diabetes, metformin has been investigated for its potential effects on Complex I activity, including NDUFS1.

Calyculin A

101932-71-2sc-24000
sc-24000A
10 µg
100 µg
$163.00
$800.00
59
(3)

This marine toxin has been studied for its potential inhibitory effects on Complex I, including NDUFS1.