NDUFA3 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is a complex I inhibitor that targets the NADH dehydrogenase complex. As NDUFA3 is a subunit of complex I, Rotenone can directly inhibit its function by hindering electron transfer from NADH to ubiquinone, thus compromising the efficiency of the electron transport chain. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $291.00 | 24 | |
Piericidin A also inhibits the NADH:ubiquinone oxidoreductase activity of complex I. By doing so, it can inhibit the function of NDUFA3 as a part of the complex, leading to a decrease in the efficiency of oxidative phosphorylation. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is known to induce mitochondrial dysfunction and can affect complex I activity. It can inhibit NDUFA3 by affecting the electron transport chain and, consequently, impairing cellular respiration. | ||||||
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base | 28289-54-5 | sc-208657 | 25 mg | $430.00 | 5 | |
MPP+ inhibits complex I and can lead to mitochondrial dysfunction. The chemical can impair the activity of NDUFA3 by inhibiting electron flow in the complex, causing disruption in the energy production pathways of the cell. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Although usually an electron carrier, in high concentrations, Coenzyme Q10 can act as an inhibitor by overwhelming the ubiquinone binding site in complex I, and thereby indirectly inhibit the activity of NDUFA3 in the electron transport chain. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib, a tyrosine kinase inhibitor, has been observed to affect mitochondrial respiration and complex I activities. Therefore, it can affect the function of NDUFA3 by impairing the electron flow in the complex. | ||||||
Deguelin | 522-17-8 | sc-200657 sc-200657A sc-200657B | 5 mg 25 mg 500 mg | $83.00 $278.00 $1894.00 | 4 | |
Deguelin inhibits NADH oxidase activity and is known for its potent inhibitory effect on complex I. This can impair the function of NDUFA3 by halting the electron transport activities within the complex. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin can inhibit complex I and is known to reduce cellular respiration. Its inhibitory action affects the efficiency of the electron transport chain, including the function of NDUFA3 as a constituent of complex I. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Chloramphenicol can inhibit mitochondrial protein synthesis, indirectly affecting complex I and thereby NDUFA3. It affects the incorporation of new subunits into the complex, thus impacting its function. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Although primarily a complex V inhibitor, Oligomycin can create a back-pressure in the electron transport chain, affecting complex I function. This can impair the activity of NDUFA3 by hindering the ability of complex I to pump protons effectively, thus inhibiting ATP synthesis. | ||||||