ncd Activators
Ncd, short for Non-claret disjunctional, is a motor protein specific to the fruit fly Drosophila melanogaster. It belongs to the kinesin superfamily, a group of proteins known for their role in transporting cellular cargo along microtubules. Ncd is distinctive for being a minus-end-directed motor, meaning it moves towards the minus end of microtubules, opposite to the direction of most kinesins.Ncd plays a crucial role in meiosis and mitosis, particularly in the formation and function of the spindle apparatus, which is essential for proper chromosome segregation during cell division. Its activity is critical for the alignment and segregation of chromosomes, ensuring that each daughter cell receives the correct number of chromosomes. This function is particularly vital during the development of gametes – sperm and egg cells – in meiosis, where precise chromosomal distribution is essential for fertility and normal embryonic development.
Ncd's mechanism involves binding to microtubules and using the energy from ATP hydrolysis to "walk" along these filaments. This movement is key to its role in manipulating the spindle fibers during cell division. Mutations or malfunctions in ncd can lead to errors in chromosome segregation, resulting in conditions like aneuploidy, where cells have an abnormal number of chromosomes, leading to developmental abnormalities or diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea induces replication stress, potentially enhancing ncd expression as part of the cell cycle checkpoint response. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, possibly upregulating ncd in response to spindle assembly checkpoint activation. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and might influence ncd expression related to spindle dynamics. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine, by disrupting microtubules, could enhance ncd expression as part of a cellular response to impaired spindle function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine affects microtubule dynamics, potentially upregulating ncd during cell cycle arrest. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin induces DNA damage, potentially triggering ncd expression in response to genomic instability. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes DNA breaks and could upregulate ncd as part of the cellular DNA damage response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin causes DNA crosslinks, potentially enhancing ncd expression in response to impaired DNA replication. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C induces DNA crosslinking, potentially enhancing ncd expression in response to replication stress. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, by causing DNA damage, may trigger ncd expression in the DNA damage checkpoint pathway. | ||||||