NCB5OR Inhibitors
NCB5OR inhibitors, short for NADH-cytochrome b5 oxidoreductase inhibitors, belong to a specific chemical class that plays a crucial role in biochemical pathways related to electron transfer and redox reactions within biological systems. These inhibitors are designed to target and modulate the activity of the NADH-cytochrome b5 oxidoreductase enzyme, also known as NCB5OR. NCB5OR is a vital enzyme found in various organisms, including humans, where it participates in electron transfer processes in both endoplasmic reticulum and mitochondrial membranes. This enzyme catalyzes the transfer of electrons from NADH (Nicotinamide Adenine Dinucleotide, reduced form) to cytochrome b5, which, in turn, participates in various metabolic reactions.
NCB5OR inhibitors typically interact with the active site of the enzyme, disrupting its normal functioning and altering the flow of electrons through the electron transport chain. These inhibitors can serve as valuable tools in scientific research to better understand the underlying mechanisms of electron transfer and redox processes in cells. Researchers use them to investigate the intricate biochemical pathways in which NCB5OR is involved, shedding light on fundamental cellular processes and the interplay between different enzymes. The study of NCB5OR inhibitors can contribute to a deeper understanding of cellular bioenergetics, redox homeostasis, and the role of specific enzymes in health and disease, although their direct applications outside of research are yet to be fully explored.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $148.00 $133.00 $311.00 $397.00 $925.00 $1801.00 | 24 | |
Diphenyleneiodonium inhibits NCB5OR by binding to its flavin cofactor, preventing the reduction of cytochrome b5, which is crucial for various cellular processes, including fatty acid desaturation. This disruption impairs electron transfer and redox reactions, affecting essential metabolic pathways. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
Nordihydroguaiaretic acid (NDGA) inhibits NCB5OR by interfering with its redox activity. NDGA acts as a non-competitive inhibitor, disrupting electron transfer reactions and impairing various cellular processes dependent on NCB5OR activity. | ||||||
Flavone | 525-82-6 | sc-206027 sc-206027A | 1 g 5 g | $23.00 $67.00 | ||
Flavone inhibits NCB5OR by binding to the enzyme's active site and disrupting its redox activity. This interference prevents the reduction of cytochrome b5, affecting metabolic pathways that rely on NCB5OR function. | ||||||
Proadifen hydrochloride | 62-68-0 | sc-200492 sc-200492A | 250 mg 1 g | $144.00 $421.00 | 1 | |
Proadifen inhibits NCB5OR by interfering with its flavin cofactor, preventing the reduction of cytochrome b5. This disruption affects the enzyme's redox activity and impairs various cellular processes, including drug metabolism. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $25.00 $35.00 $46.00 $133.00 $446.00 | 3 | |
Menadione inhibits NCB5OR by acting as a competitive inhibitor of the enzyme's substrate, NADH. This interference disrupts electron transfer and redox reactions, impacting metabolic pathways that rely on NCB5OR activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits NCB5OR by interfering with electron transfer in the mitochondrial respiratory chain. While not a direct NCB5OR inhibitor, it indirectly affects its activity by disrupting the overall electron transport system. | ||||||
Aminoglutethimide | 125-84-8 | sc-207280 sc-207280A sc-207280B sc-207280C | 1 g 5 g 25 g 100 g | $41.00 $143.00 $530.00 $2020.00 | 2 | |
Aminoglutethimide inhibits NCB5OR by blocking the enzyme's flavin cofactor. This disruption impairs the reduction of cytochrome b5, affecting steroid hormone synthesis and other NCB5OR-dependent metabolic pathways. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetylcysteine (NAC) indirectly affects NCB5OR by replenishing intracellular glutathione levels. NAC helps combat oxidative stress, which can indirectly improve NCB5OR function by reducing cellular damage caused by ROS. | ||||||