Natural Killer Cell Activators
The activation and functionality of Natural Killer (NK) cells are critically influenced by various chemical compounds that modulate immune signaling pathways and cellular processes. Compounds such as 1,25-Dihydroxyvitamin D3 and Beta-Glucan enhance NK cell activity through different mechanisms. While 1,25-Dihydroxyvitamin D3 modulates the immune response, enhancing the expression of NK cell receptors and their cytotoxicity, Beta-Glucan boosts NK cell-mediated cytotoxicity by activating the Dectin-1 pathway. Similarly, Artesunate indirectly augments NK cell activity by increasing the susceptibility of malignant cells to NK cell-mediated lysis, highlighting the role of cellular stress in cancer cell targeting. Resveratrol and Curcumin further contribute to the activation of NK cells by modulating sirtuin pathways and NF-κB signaling, respectively, which are essential for the regulation of immune cell function and the inflammatory response, thus supporting the cytotoxic activity of NK cells against tumor cells.
Moreover, essential nutrients and antioxidants like Zinc Sulphate, Selenium Sulfide, and Vitamin E (α-Tocopherol) play significant roles in enhancing NK cell function by improving the immune system's overall health. Zinc Sulphate is crucial for the development and activation of NK cells, whereas Selenium Sulfide and Vitamin E protect immune cells from oxidative stress, thereby maintaining their functionality. Phytochemicals such as Ginsenoside Rg3, Quercetin, Epigallocatechin Gallate, and Lycopene potentiate NK cell activity by influencing various signaling pathways, including those involved in the immune response and antioxidant defenses. These compounds, through their targeted effects on cellular signaling and immune regulation, facilitate the enhancement of NK cell-mediated functions, showcasing the intricate interplay between chemical compounds and immune cell activation in the body's defense against malignancies and infections.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Enhances NK cell activity by modulating the immune response. It influences the expression of NK cell receptors and enhances their cytotoxicity through the regulation of calcium and phosphorus metabolism, indirectly supporting NK cell activation. | ||||||
Artesunate | 88495-63-0 | sc-201329 sc-201329A | 10 mg 50 mg | $62.00 $288.00 | 5 | |
Indirectly augments NK cell activity by causing cellular stress in malignant cells, making them more susceptible to NK cell-mediated lysis. Artesunate's impact on the redox balance in cancer cells can trigger an enhanced immune response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Activates NK cells by modulating sirtuin pathways, which are involved in the regulation of immune cell function. Resveratrol's antioxidant properties also support NK cell activity by reducing oxidative stress in the immune environment. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Enhances NK cell function by modulating NF-κB signaling, leading to an improved inflammatory response and increased cytotoxic activity of NK cells. Curcumin's effect on this pathway indirectly supports NK cell-mediated immunity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Supports NK cell activity by enhancing the production and function of immune cells through improved zinc status. Zinc is crucial for maintaining the function of immune cells, including NK cells, by supporting their development and activation. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $62.00 | 1 | |
Indirectly enhances NK cell function by improving the antioxidant capacity and reducing oxidative stress in immune cells. Selenium's role in immune regulation supports the activation and function of NK cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Enhances NK cell activity by modulating inflammatory responses and supporting antioxidant defenses. Quercetin's impact on signaling pathways relevant to immune cell function indirectly supports NK cell-mediated cytotoxicity. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 $430.00 | ||
Supports NK cell activity by protecting immune cells from oxidative stress, thus maintaining their functionality. Vitamin E's antioxidant effect is crucial for the optimal function of NK cells and their activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Potentiates NK cell activity through the modulation of NF-κB and other signaling pathways, enhancing the immune response and NK cell-mediated cytotoxicity, especially against tumor cells. | ||||||
Lycopene | 502-65-8 | sc-205738 sc-205738A sc-205738B | 1 mg 5 mg 1 g | $146.00 $582.00 $6248.00 | 4 | |
Enhances NK cell function by modulating immune responses through antioxidant properties. Lycopene's ability to reduce oxidative stress supports the activation and function of NK cells in the immune system. | ||||||