Natural Killer Cell Antibody (H25): sc-53384

Natural Killer Cell Antibody (H25) is a mouse monoclonal IgG1 antibody that detects Natural Killer Cell protein (NK) of human origin by immunoprecipitation (IP). Natural Killer Cell (H25) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NK cells are crucial components of the innate immune system, originating from bone marrow and characterized by their large granular appearance. These lymphocytes play a vital role in the immune response by identifying and eliminating cells that have been infected by pathogens, particularly viruses. NK cells exert cytotoxic effects through the release of specialized proteins, including perforin and granzymes. Perforin forms pores in the membranes of target cells, facilitating the entry of granzymes, which are serine proteases that induce apoptosis in the infected cells. This process is essential for controlling viral infections and preventing the spread of pathogens within the body. Notably, individuals with deficiencies in NK cell function are at a significantly higher risk for severe infections, such as those caused by the herpes virus, underscoring the importance of these cells in maintaining immune health.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Natural Killer Cell Antibody (H25) References:

1. On guard--activating NK cell receptors.  |  Lanier, LL. 2001. Nat Immunol. 2: 23-7. PMID: 11135574
2. The biology of human natural killer-cell subsets.  |  Cooper, MA., et al. 2001. Trends Immunol. 22: 633-40. PMID: 11698225
3. Biology and clinical relevance of human natural killer cells.  |  Robertson, MJ. and Ritz, J. 1990. Blood. 76: 2421-38. PMID: 2265240
4. Immunophenotypic demonstration of two natural killer surface markers, H25 and H366, on fresh human leukemic cells.  |  Körfer, A., et al. 1989. Acta Haematol. 82: 193-6. PMID: 2511721
5. Two monoclonal antibodies identifying a subset of human peripheral mononuclear cells with natural killer cell activity.  |  Bai, Y., et al. 1983. Eur J Immunol. 13: 521-7. PMID: 6603362
6. Activation and function of natural killer cell responses during viral infections.  |  Biron, CA. 1997. Curr Opin Immunol. 9: 24-34. PMID: 9039782
7. The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity.  |  Brown, MG., et al. 1997. Immunol Rev. 155: 53-65. PMID: 9059882
8. Signal transduction during natural killer cell activation: inside the mind of a killer.  |  Leibson, PJ. 1997. Immunity. 6: 655-61. PMID: 9208838

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Natural Killer Cell Antibody (H25) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Natural Killer Cell Antibody (H25) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Natural Killer Cell Antibody (H25) Specifications

Alternate Product Name: Natural Killer Cell

Product Clone Name: H25

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁/IgG_2a

Amino Acids:

Epitope Target: Natural Killer Cell

Epitope Species: human

Product Reactivity/Detection: NK cells

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP

Vialing Information: Each vial contains 200 µg IgG₁/IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Natural Killer Cell Antibody (H25): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin