NanogNB Inhibitors
NanogNB inhibitors are a class of small molecules or compounds designed to interfere with the activity of NanogNB, a variant of the Nanog transcription factor, which plays a key role in maintaining pluripotency and self-renewal capabilities in stem cells. NanogNB belongs to a family of homeobox proteins that bind DNA and regulate gene expression crucial for early embryonic development and cellular differentiation. NanogNB inhibitors specifically target the DNA-binding domain or other regulatory domains of the NanogNB protein, preventing it from interacting with its genetic targets. By disrupting these interactions, the inhibitors can alter the expression patterns of genes responsible for maintaining undifferentiated cell states and pluripotency, thereby promoting differentiation pathways or halting uncontrolled cell growth. These inhibitors are primarily used in experimental and research settings where modulating stem cell behavior or studying developmental biology is a central focus.
The chemical structure of NanogNB inhibitors typically consists of molecular scaffolds that allow them to bind with high specificity to the active sites of the NanogNB protein. They often exhibit strong hydrophobic interactions with amino acid residues in the protein's binding pocket or may form hydrogen bonds with key residues to stabilize the inhibitory complex. In some instances, these inhibitors are capable of inducing allosteric changes in the NanogNB protein, leading to a conformational shift that reduces its functional activity. Researchers commonly use these inhibitors to explore fundamental processes such as lineage commitment, cellular differentiation, and the regulation of pluripotency by NanogNB and related factors in developmental biology. By providing insights into how NanogNB regulates gene networks, these inhibitors help further our understanding of cell state transitions, epigenetic regulation, and transcriptional hierarchies in stem cell systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3Ks), which play a role in the Akt signaling pathway. The inhibition of PI3Ks leads to reduced Akt phosphorylation and activity, which is necessary for the stability and function of NANOG neighbor homeobox, thereby inhibiting its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that operates by irreversibly binding to the PI3Ks, inhibiting Akt signaling. This results in decreased phosphorylation and activation of downstream targets essential for the functional activity of NANOG neighbor homeobox, leading to its inhibition. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically inhibits mTORC1, which is part of the mTOR pathway that is linked to the regulation of NANOG neighbor homeobox through control of cellular growth and proliferation signals that can influence its function. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB 431542 is an inhibitor of the TGF-β receptor kinase. TGF-β signaling is involved in the differentiation pathways that can inhibit the function of NANOG neighbor homeobox by promoting the differentiation of cells where NANOG neighbor homeobox is active. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
GSK-3 Inhibitor XVI is a GSK-3β inhibitor which can lead to the stabilization of β-catenin, a component of the Wnt signaling pathway. This inhibition can reduce the expression of differentiation factors that would otherwise inhibit the function of NANOG neighbor homeobox. | ||||||
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $60.00 $150.00 $226.00 $495.00 | 1 | |
Kenpaullone is a GSK-3β inhibitor that can lead to altered Wnt signaling pathway activity, inhibiting the differentiation signals that can downregulate the function of NANOG neighbor homeobox. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor, and by inhibiting ROCK, it can alter cytoskeletal dynamics and cellular mechanics, which are known to influence the function of transcription factors like NANOG neighbor homeobox, leading to its functional inhibition. | ||||||
PD 184,352 | 212631-79-3 | sc-202759 sc-202759A | 1 mg 5 mg | $39.00 $255.00 | 34 | |
PD 184,352 is a MEK inhibitor that, like PD 0325901, disrupts the MEK/ERK pathway, which is involved in the regulation of NANOG neighbor homeobox through modulation of transcription factor activity and cellular differentiation. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Gö 6983 is a protein kinase C inhibitor that can disrupt signaling necessary for cellular differentiation and proliferation, processes that are necessary for the proper function of NANOG neighbor homeobox, thus leading to its inhibition. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is an mTOR kinase inhibitor, targeting both mTORC1 and mTORC2 complexes. By inhibiting mTOR signaling, AZD8055 can disrupt the signaling environment required for NANOG neighbor homeobox function, resulting in its inhibition. | ||||||