Myosin VIIB Activators
The class of chemicals described as Myosin VIIB Activators encompasses a diverse range of compounds that influence myosin activity indirectly through modulation of signaling pathways and biochemical processes within the cell. These activators work by altering the concentration of intracellular messengers such as calcium, which is pivotal for the function of enzymes like myosin light chain kinase (MLCK) that phosphorylate myosin light chains, thereby modulating myosin motor activity. Additionally, compounds like ATP and magnesium are fundamental for the actual motor function of myosins, providing the energy and structural support necessary for conformational changes during muscle contraction and cellular movements.
Furthermore, secondary messenger modulators such as forskolin and EGF alter the phosphorylation state of myosin through the activation of kinases like PKA and PKC, or through the inhibition of phosphatases with compounds like okadaic acid and calyculin A. This can result in enhanced myosin activity, as phosphorylation is a common regulatory mechanism for activating myosin motors.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Increases intracellular Ca2+ levels, which can activate myosin light chain kinase leading to myosin activation. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
Supplies energy for myosin motor activity and its binding is crucial for myosin's conformational changes. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium is required as a cofactor for ATP binding to myosins, necessary for its motor function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Elevates cAMP, which can activate PKA leading to phosphorylation and potential activation of myosin light chains. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C (PKC) which can phosphorylate and modulate myosin light chain activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Inhibits protein phosphatases 1 and 2A, potentially increasing phosphorylation of myosin light chains, enhancing activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Similar to okadaic acid, it inhibits protein phosphatases leading to increased myosin light chain phosphorylation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Activates PI3K/Akt signaling pathway which can lead to myosin light chain kinase (MLCK) activation. | ||||||