myomesin-2 Activators
Myomesin-2 activators comprise a diverse set of chemical compounds that indirectly bolster the functional activity of myomesin-2 through a variety of cellular signaling pathways and biochemical mechanisms. Forskolin, for instance, catalyzes the conversion of ATP to cyclic AMP, leading to the activation of protein kinase A (PKA), which is known to phosphorylate proteins within the sarcomere, potentially enhancing the structural role of myomesin-2 in muscle contraction dynamics. Similarly, phosphocreatine, by serving as a phosphate reservoir, aids in maintaining ATP levels, ensuring the energy-dependent stability of myomesin-2 within the sarcomere's M-band during muscle contractions. The green tea polyphenol, Epigallocatechin gallate (EGCG), as a kinase inhibitor, may alter the phosphorylation status of sarcomeric proteins, potentially boosting the assembly and function of the M-band where myomesin-2 resides. Moreover, sphingosine-1-phosphate, acting through lipid signaling pathways, and Dibutyryl-cAMP, an analog of cAMP, both potentiate PKA signaling, which could indirectly modulate the activity of myomesin-2, implicating its role in sarcomere integrity and muscle contraction.
The suite of myomesin-2 enhancers also includes molecules like nicotinamide riboside, which by augmenting NAD+ biosynthesis, supports the cellular metabolism crucial for myomesin-2's energy-demanding activities during prolonged muscle exertion. Resveratrol activates sirtuin pathways, affecting deacetylation processes that might tweak myomesin-2's interactions within the sarcomere, potentially fine-tuning muscle function. Additionally, caffeine's phosphodiesterase inhibition raises cAMP levels, indirectly promoting myomesin-2's contribution to the sarcomere's mechanical efficiency, whereas omega-3 fatty acids, by integrating into cell membranes, could indirectly affect myomesin-2 function by optimizing the sarcomeric response to mechanical stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased levels of cyclic AMP (cAMP) in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate various substrates, potentially including those in the sarcomere where myomesin-2 is located, thus enhancing its functionality in muscle contraction and structural integrity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
As a kinase inhibitor, Epigallocatechin gallate (EGCG) may influence the phosphorylation states of proteins within the sarcomere. By modulating kinase activity, EGCG could enhance the role of myomesin-2 in the M-band assembly and function, which is critical in muscle contraction. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
This lipid signaling molecule can activate signal transduction pathways that lead to cytoskeletal rearrangements. Its effects on the actin-myosin interaction could enhance the structural role of myomesin-2 in the sarcomere by stabilizing the M-band during muscle contraction and relaxation cycles. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
A cell-permeable cAMP analog that activates PKA. By enhancing PKA signaling, it could indirectly increase the activity of myomesin-2 by affecting its phosphorylation state, thus promoting its structural and regulatory roles in the M-band of the sarcomere. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
As a precursor for NAD+ biosynthesis, nicotinamide riboside can enhance cellular metabolism and energy availability. Increased NAD+ levels can support the energy-demanding activities of myomesin-2, especially during sustained muscle contractions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a deacetylase that can modulate the activity of various proteins through deacetylation. This activation may indirectly enhance the function of myomesin-2 by altering its interaction with other sarcomeric proteins, thereby affecting muscle function and contraction. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels and subsequent PKA activation. This cascade can enhance myomesin-2 function by modulating phosphorylation states of sarcomeric proteins, potentially improving muscle contraction efficiency. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Omega-3 fatty acids can incorporate into cell membranes, altering membrane fluidity and potentially affecting membrane-associated signaling pathways. This can indirectly influence the function of myomesin-2 by modulating its interaction within the M-band and its response to mechanical stress during muscle contraction. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences various signaling pathways, including the glycogen synthase kinase-3 (GSK-3) pathway. By inhibiting GSK-3, lithium chloride could indirectly enhance myomesin-2 activity by affecting the phosphorylation states of proteins within the sarcomere, potentially improving structural integrity and function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A polyphenol that can affect various signaling pathways, including those related to inflammation and oxidative stress. Curcumin's modulation of these pathways could indirectly affect myomesin-2's role in the sarcomere by preserving muscle tissue integrity and enhancing its response to mechanical stimuli. | ||||||