MYL3 Activators
Myosin Light Chain 3 (MYL3) Activators encompass a diverse array of chemical compounds that directly or indirectly enhance the functional activity of MYL3, a critical protein in cardiac muscle contraction. Compounds such as Calmodulin, by facilitating the binding of MYL3 to myosin heavy chains, effectively enhance the calcium sensitivity of myofilaments, a pivotal step for muscle contraction. Similarly, Forskolin, Dobutamine, Isoproterenol, and Caffeine all lead to increased cAMP levels, which activate protein kinase A (PKA). The activated PKA phosphorylates MYL3, which is an essential post-translational modification that augments myocardial contractility. Phosphodiesterase inhibitors like Milrinone and Sildenafil elevate cAMP or cGMP levels, respectively, further perpetuating the activation of PKA and subsequent enhancement of MYL3 activity.
The chemical class referred to as Myosin Light Chain 3 (MYL3) Activators has been a subject of in-depth investigation due to its potential to modulate the activity of MYL3, a protein integral to muscle contraction and sarcomere function. Within this chemical class, specific compounds have been identified that can selectively enhance the transcriptional activity of MYL3, and the exploration of MYL3 activators involves a comprehensive approach. Cutting-edge techniques, such as co-immunoprecipitation, have been instrumental in studying the physical interactions between MYL3 and its activators. These methods enable researchers to pinpoint specific binding sites and assess the strength and specificity of the MYL3-activator complex.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin binds to Myosin Light Chain 3, facilitating its interaction with myosin heavy chains. This enhances the contraction process in cardiac muscles by increasing the calcium sensitivity of the myofilaments. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which subsequently activate PKA. PKA phosphorylates Myosin Light Chain 3, enhancing its activity which is crucial for muscle contraction. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine is a beta-1 adrenergic agonist that increases cAMP in cardiac cells, leading to the activation of PKA. PKA then phosphorylates Myosin Light Chain 3, improving cardiac muscle contractility. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol, a non-selective beta-adrenergic agonist, increases intracellular cAMP and activates PKA. PKA phosphorylates Myosin Light Chain 3, leading to an increase in myocardial contractility. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone inhibits phosphodiesterase 3, leading to increased cAMP and activation of PKA, which subsequently phosphorylates Myosin Light Chain 3, improving cardiac muscle contraction. | ||||||
Levosimendan | 141505-33-1 | sc-204792 sc-204792A | 100 mg 250 mg | $104.00 $228.00 | ||
Levosimendan sensitizes troponin C to calcium, indirectly enhancing the function of Myosin Light Chain 3 by improving the calcium responsiveness of the cardiac myofilaments. | ||||||
Omecamtiv Mecarbil | 873697-71-3 | sc-507399 | 5 mg | $255.00 | ||
Omecamtiv Mecarbil directly activates myosin ATPase by stabilizing the actin-myosin complex, which indirectly enhances the activity of Myosin Light Chain 3 by increasing its interaction with actin, leading to improved cardiac contractility. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin inhibits the Na+/K+ ATPase pump, leading to an increase in intracellular calcium concentration. This increase can enhance the calcium-mediated activation of Myosin Light Chain 3, leading to stronger cardiac muscle contractions. | ||||||