Molecular structure of Omecamtiv Mecarbil, CAS Number: 873697-71-3
Omecamtiv Mecarbil (CAS 873697-71-3)
Alternate Names:
CK-1827452, 4-[[2-fluoro-3-[[[(6-methyl-3-pyridinyl)amino]carbonyl]amino]phenyl]methyl]-1-piperazinecarboxylic acid, methyl ester
CAS Number:
873697-71-3
Molecular Weight:
401.4
Molecular Formula:
C20H24FN5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Omecamtiv Mecarbil (CAS 873697-71-3) References
- Omecamtiv Mecarbil: A Myosin Motor Activator Agent with Promising Clinical Performance and New in vitro Results. | Nanasi, P., et al. 2018. Curr Med Chem. 25: 1720-1728. PMID: 29278207
- Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF. | Teerlink, JR., et al. 2020. JACC Heart Fail. 8: 329-340. PMID: 32035892
- Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure. | Teerlink, JR., et al. 2021. N Engl J Med. 384: 105-116. PMID: 33185990
- Omecamtiv Mecarbil: A Novel Mechanistic and Therapeutic Approach to Chronic Heart Failure Management. | Patel, PH., et al. 2021. Cureus. 13: e12419. PMID: 33542867
- Omecamtiv Mecarbil use in systolic heart failure- Results of the GALACTIC-HF trial. | Shah, SR., et al. 2021. Expert Rev Clin Pharmacol. 14: 407-409. PMID: 33689561
- Omecamtiv Mecarbil: A Personalized Treatment for Patients With Severely Impaired Ejection Fraction. | Ferreira, JP. 2021. J Am Coll Cardiol. 78: 109-111. PMID: 34015476
- Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations. | Trivedi, A., et al. 2022. Br J Clin Pharmacol. 88: 187-198. PMID: 34131942
- Safety and efficacy of omecamtiv mecarbil for heart failure: A systematic review and meta-analysis. | Alqatati, F., et al. 2022. Indian Heart J. 74: 155-162. PMID: 35301008
- Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial. | Lewis, GD., et al. 2022. JAMA. 328: 259-269. PMID: 35852527
- Omecamtiv Mecarbil in the treatment of heart failure: the past, the present, and the future. | Zhou, S., et al. 2024. Front Cardiovasc Med. 11: 1337154. PMID: 38566963
Inhibitor of:
C10orf104, C6orf126, C9orf16, FLJ31485, LOC100041308, LOC100041422, LOC643714, LOC646237, LOC728675, LOC729504, LOC729508, LOC729791, LOC729886, LOC729928, MYH7, MyoD, Myosin, QTRTD1, sMtCK, Troponin I-FS, and Troponin T-C.Activator of:
MYL3, myomesin-1, and Myosin Ia.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Omecamtiv Mecarbil, 5 mg | sc-507399 | 5 mg | $255.00 |