Molecular structure of Levosimendan, CAS Number: 141505-33-1
Levosimendan (CAS 141505-33-1)
Alternate Names:
Simdax; Mesoxalonitrile (−)-(p((R)-1,4,5,6-tetrahydro-4-methyl-6- oxo-3-pyridazinyl)phenyl)hydrazone
Application:
Levosimendan is a Ca2+ sensitizer that increases contractile force of the myocardium
CAS Number:
141505-33-1
Purity:
≥99%
Molecular Weight:
280.28
Molecular Formula:
C14H12N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Levosimendan is a Ca2+ sensitizer that increases contractile force of the myocardium by enhancing the sensitivity of myofilaments to calcium without increasing intracellular calcium concentration. Levosimendan has been shown to reduce circulating proinflammatory cytokine interleukin-6 and soluble apoptosis mediators. Levosimendan is an inhibitor of PDE.
Levosimendan (CAS 141505-33-1) References
Udvary E, Papp JG, Vegh A. Br J Pharmacol. 114:656-61 (1995). Parissis JT, Adamopoulos S, Antoniades C et al. Am J Cardiol. 93:1309-12 (2004). Eriksson O, Pollesello P, Haikala H. J Cardiovasc Pharmacol. 44:316-21 (2004).Inhibitor of:
HMG-2L1, and PDE.Activator of:
CaMKIIγ, L-type Ca++ CP γ3, LRRC10, MYBPC3, MYH15, MYL3, Triadin, Troponin I-C, and Troponin T-C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Levosimendan, 100 mg | sc-204792 | 100 mg | $104.00 | |||
Levosimendan, 250 mg | sc-204792A | 250 mg | $228.00 |