MYL10 Activators
MYL10 activators pertain to a chemical class designed to modulate the biological activity of the protein myosin light chain 10 (MYL10), also known as the regulatory light chain of myosin II. Myosin is a motor protein that plays a crucial role in muscle contraction and various cellular movements by converting chemical energy in the form of ATP into mechanical energy. MYL10 is one of the essential components of the myosin complex, which functions in the regulation of myosin activity. Activators of MYL10 influence the protein's function by enhancing its interaction with myosin, which can lead to conformational changes in the myosin molecule, affecting its motor activity.
The interaction between MYL10 and the myosin heavy chain is a finely tuned mechanism that is central to muscle and non-muscle cell contraction. The regulation of this interaction is complex and involves the phosphorylation of MYL10, which results in a change in myosin II's ATPase activity, ultimately altering the dynamics of muscle contraction and cellular motility. MYL10 activators modulate this process by binding to MYL10 and affecting its phosphorylation state or by acting on the allosteric sites that influence the MYL10-myosin interaction. By doing so, these molecules can induce a cascade of biochemical events within the cell that are critical for the modulation of myosin II's activity. The precise molecular mechanisms of how MYL10 activators exert their effects on MYL10 and myosin function are the subject of ongoing scientific investigation. These studies focus on understanding the biochemistry and structural biology underlying the myosin-MYL10 interaction and how it is affected by the presence of these activating compounds.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly increases the levels of cyclic AMP (cAMP) within cells. Elevated cAMP levels can lead to the activation of protein kinase A (PKA), which can phosphorylate and thereby enhance the activity of MYL10, contributing to its role in muscle contraction and regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate specific target proteins. Activation of PKC has been shown to influence the phosphorylation state and activity of myosin light chains such as MYL10, leading to modulation of muscle contraction and cellular motility. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), enzymes that dephosphorylate myosin light chains. By inhibiting these phosphatases, Calyculin A maintains MYL10 in a phosphorylated and thus activated state, promoting muscle contraction. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. Upon activation, PKA can phosphorylate and activate MYL10, leading to enhanced muscle contraction. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP levels by stimulating adenylyl cyclase. The increase in cAMP activates PKA, which can then phosphorylate and activate MYL10. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of PP1 and PP2A, similar to Calyculin A. It prevents the dephosphorylation of MYL10, maintaining its phosphorylated, active state, which is vital for muscle contraction. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine interacts with beta-adrenergic receptors to increase cAMP levels, activating PKA. PKA then phosphorylates MYL10, enhancing its activity and role in muscle contraction and regulation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK). Inhibition of ROCK leads to reduced phosphorylation of myosin light chain phosphatase, thereby increasing phosphorylation and activation of MYL10. | ||||||