MYH4 Inhibitors
Common MYH4 Inhibitors include, but are not limited to (±)-Blebbistatin CAS 674289-55-5, ML-7 hydrochloride CAS 110448-33-4, Y-27632, free base CAS 146986-50-7, CK 666 CAS 442633-00-3 and BTS CAS 1576-37-0.
MYH4 inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of the MYH4 protein. MYH4, also known as myosin heavy chain 4, is a motor protein that plays a critical role in muscle contraction. It is a component of the thick filaments in skeletal muscle cells and is involved in converting chemical energy from ATP into mechanical work, leading to muscle contraction and movement.
MYH4 inhibitors work by specifically targeting the MYH4 protein, interfering with its ability to interact with actin filaments and generate force during muscle contraction. By doing so, these inhibitors may modulate the contractile properties of muscle cells and impact muscle function. Research into MYH4 and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in muscle physiology. The study of MYH4 inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricate mechanisms governing muscle contraction and function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is a small molecule that can inhibit myosin II activity by preventing its interaction with actin. It specifically targets the motor domain of myosin II, leading to reduced actin-myosin cross-bridge formation and inhibition of muscle contraction. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is a selective inhibitor of myosin light chain kinase (MLCK), which indirectly affects myosin II activity by reducing myosin light chain phosphorylation. This leads to decreased myosin II activity and impaired muscle contractility. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a potent and selective inhibitor of Rho-associated protein kinase (ROCK), which indirectly affects myosin II activity through modulation of myosin light chain phosphorylation. It leads to reduced myosin II-mediated contractility in smooth muscle and non-muscle cells. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is a specific inhibitor of the Arp2/3 complex, an actin nucleation factor involved in actin filament branching. While not directly targeting MYH4, CK-666 can influence the dynamics of the actin cytoskeleton, potentially impacting MYH4-dependent processes in muscle cells. | ||||||
BTS | 1576-37-0 | sc-202087 sc-202087A sc-202087B | 5 mg 250 mg 5 g | $20.00 $52.00 $163.00 | 1 | |
BTS (N-benzyl-p-toluene sulphonamide) is a broad-spectrum myosin inhibitor that affects both myosin II and myosin V. It inhibits ATPase activity and actin binding of myosin, leading to impaired actin-myosin interactions and disrupted cellular functions dependent on myosin. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
Thiazovivin is a selective inhibitor of ROCK that indirectly affects myosin II activity by modulating myosin light chain phosphorylation. It reduces actin-myosin cross-bridge formation and cell contractility, which can impact MYH4-dependent functions in muscle cells. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is an inhibitor of myosin light chain kinase (MLCK), which indirectly affects myosin II activity by reducing myosin light chain phosphorylation. This leads to decreased myosin II activity and impaired muscle contractility. | ||||||
CK-689 | 170930-46-8 | sc-507371 | 25 mg | $312.00 | ||
CK-689 is a specific inhibitor of the Arp2/3 complex, an actin nucleation factor involved in actin filament branching. While not directly targeting MYH4, CK-689 can influence the dynamics of the actin cytoskeleton, potentially impacting MYH4-dependent processes in muscle cells. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is a specific inhibitor of the Arp2/3 complex, an actin nucleation factor involved in actin filament branching. While not directly targeting MYH4, CK-869 can influence the dynamics of the actin cytoskeleton, potentially impacting MYH4-dependent processes in muscle cells. | ||||||