MYBPC1 Inhibitors
The classification termed MYBPC1 Inhibitors primarily encompasses compounds that target pathways and processes indirectly linked to the functions of MYBPC1, a protein essential for muscle contraction. In the realm of muscle contraction, the coordinated action of actin, myosin, and a plethora of auxiliary proteins like MYBPC1 is of paramount importance. Consequently, compounds like Blebbistatin, ML-7, and BDM, which respectively inhibit myosin ATPase activity, myosin light chain kinase, and myosin-actin interactions, provide substantial insights into the modulation of MYBPC1 dynamics and its interplay within the sarcomere.
On another front, phosphorylation plays a vital role in muscle function regulation. KN-93, Calyculin A, and Gö 6983 target kinase pathways and phosphatases, influencing the phosphorylation status of proteins linked to MYBPC1, thus modifying its function. Furthermore, considering the essential roles of actin in muscle contraction, actin-targeting agents like Cytochalasin D and Latrunculin A disrupt actin dynamics, impacting MYBPC1's interactions and position in the sarcomere. These inhibitors, through their varied mechanisms, underline the intricate interplay of cellular components within muscle cells and emphasize the indirect but plausible modulation of MYBPC1's function within this intricate cellular machinery.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $179.00 $307.00 $455.00 $924.00 $1689.00 | 7 | |
Inhibits myosin II ATPase activity, and can thus affect proteins, like MYBPC1, associated with myosin function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
Inhibits myosin light chain kinase, potentially influencing the phosphorylation status of sarcomeric proteins related to MYBPC1. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor that affects myosin light chain phosphorylation, which might impact MYBPC1-associated functions. | ||||||
2,3-Butanedione 2-Monoxime | 57-71-6 | sc-203774 sc-203774A sc-203774B sc-203774C | 25 g 100 g 250 g 500 g | $41.00 $76.00 $158.00 $280.00 | ||
Interferes with muscle contraction by inhibiting myosin-actin interaction, potentially affecting MYBPC1 dynamics. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor which can affect several cellular processes including those related to muscle contraction and potentially MYBPC1. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
CaMKII inhibitor that affects calcium signaling in muscles, potentially influencing MYBPC1 function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Disrupts actin filaments, potentially affecting MYBPC1's interactions in the sarcomere. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Binds to actin monomers, preventing polymerization and thus potentially affecting MYBPC1 function. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Inhibits protein phosphatases PP1 and PP2A, altering the phosphorylation status of sarcomeric proteins that can impact MYBPC1. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Broad-spectrum kinase inhibitor which might affect kinases relevant to MYBPC1 function. | ||||||