Mumps Inhibitors
Mumps inhibitors are chemicals that can interfere with various aspects of the Mumps viral life cycle, either through direct interaction with viral components or by modulating host cellular mechanisms. IMPDH inhibitors like Ribavirin and Mycophenolic Acid reduce intracellular pools of GTP, effectively stunting viral RNA synthesis. Similarly, Guanidine Hydrochloride directly inhibits the viral RNA polymerase, while 2'-C-methyladenosine causes premature termination of viral RNA. Chloroquine endosomal fusion by alkalinizing the endosomal pH, thereby obstructing the entry of the viral genome into the host cell. In the class of protein-targeting inhibitors, Amantadine alters proton flux by binding to the M2 ion channel protein, viral uncoating. Cycloheximide and Nelfinavir target eukaryotic translation and viral protease, respectively, thereby halting viral protein synthesis and maturation.
Further strategies to inhibit Mumps replication focus on manipulating host cell mechanisms. 2-deoxy-D-glucose interferes with cellular ATP levels by inhibiting glycolysis, leading to ineffective viral assembly and budding. Levamisole enhances host T-cell responses, which increases interferon-gamma production, further hindering viral replication through immune activation. In summary, Mumps inhibitors can act by disrupting viral replication and assembly, obstructing the viral entry and uncoating processes, and by bolstering host immune responses. Each chemical acts at a specific step in the Mumps life cycle, either by targeting viral components or through interaction with host cellular pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
Inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH) leading to depletion of intracellular GTP pools. This disrupts viral RNA synthesis, hindering the replication of the Mumps virus. | ||||||
1-Adamantylamine | 768-94-5 | sc-251475 sc-251475A | 1 g 25 g | $38.00 $144.00 | ||
Targets the M2 ion channel protein of the mumps virus, altering proton flux across the viral envelope. This interferes with the viral uncoating process, inhibiting the release of the Mumps viral RNA into the host cell. | ||||||
Acyclovir | 59277-89-3 | sc-202906 sc-202906A | 50 mg 500 mg | $147.00 $922.00 | 2 | |
Acts as a viral DNA polymerase inhibitor but requires activation by viral thymidine kinase. In Mumps, it is less effective but can inhibit the viral RNA polymerase to some extent by competition with natural nucleosides. | ||||||
Guanidine Hydrochloride | 50-01-1 | sc-202637 sc-202637A | 100 g 1 kg | $60.00 $195.00 | 1 | |
Inhibits the activity of viral RNA polymerase, impeding the replication of the Mumps virus. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Alkalinizes endosomal pH, which interferes with the fusion of the Mumps virus to the host cell membrane, preventing the release of the viral genome into the host cell. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis by blocking translocation, thereby preventing the Mumps viral proteins from being manufactured in the host cell machinery. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits IMPDH, reducing GMP synthesis and thereby affecting viral RNA synthesis, which leads to a decrease in the Mumps virus replication. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Interacts with the receptor-binding domain of the Mumps viral proteins, preventing the attachment of the virus to the host cell surface receptors. | ||||||
Levamisole Hydrochloride | 16595-80-5 | sc-205730 sc-205730A | 5 g 10 g | $42.00 $67.00 | 18 | |
Enhances host immune responses by stimulating T-cell activity, leading to increased production of interferon-gamma that limits Mumps viral replication through activation of immune pathways. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Inhibits cellular glycolysis, reducing the cellular ATP levels which are necessary for the Mumps viral replication cycle, specifically during the assembly and budding stages. | ||||||