Date published: 2025-10-21

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Mucin 5AC Inhibitors

Mucin 5AC inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of Mucin 5AC. Mucin 5AC is a high molecular weight glycoprotein that belongs to the family of mucins, which are involved in protecting and lubricating epithelial surfaces. Mucin 5AC is predominantly expressed in the respiratory tract, stomach, and other mucosal tissues. It plays a crucial role in forming the protective mucus layer that covers the epithelial surfaces and serves as a barrier against pathogens, toxins, and mechanical stress. Mucin 5AC inhibitors work by specifically targeting the Mucin 5AC protein, interfering with its synthesis, secretion, or function. By doing so, these inhibitors may modulate the production and composition of mucus, affecting the protective properties of the mucus layer and the interactions between epithelial cells and the external environment. Research into Mucin 5AC and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in mucosal biology. The study of Mucin 5AC inhibitors represents an intriguing area of research, contributing to a deeper understanding of the intricate mechanisms governing mucosal protection and homeostasis.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Sivelestat

127373-66-4sc-203938
1 mg
$105.00
2
(1)

Inhibits neutrophil elastase, reducing the proteolytic cleavage of MUC5AC and its secretion, potentially suppressing mucus production and inflammation in respiratory diseases.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

Modulates MUC5AC expression and secretion, reducing airway mucus production and inflammation in respiratory disorders through its anti-inflammatory and antioxidant properties.

N-Acetyl-L-cysteine

616-91-1sc-202232
sc-202232A
sc-202232C
sc-202232B
5 g
25 g
1 kg
100 g
$33.00
$73.00
$265.00
$112.00
34
(1)

Acts as a mucolytic agent, breaking down disulfide bonds within MUC5AC and other mucins, reducing mucus viscosity and facilitating its clearance in respiratory conditions.

Scopoletin

92-61-5sc-206059
sc-206059A
50 mg
100 mg
$97.00
$178.00
4
(1)

Downregulates MUC5AC expression and secretion, potentially reducing mucus production and inflammatory responses in respiratory diseases.

Naproxen

22204-53-1sc-200506
sc-200506A
1 g
5 g
$24.00
$40.00
(1)

Exhibits anti-inflammatory properties, potentially reducing MUC5AC expression and secretion and attenuating mucus hypersecretion in respiratory inflammatory conditions.

Berberine

2086-83-1sc-507337
250 mg
$90.00
1
(0)

Downregulates MUC5AC expression and secretion, potentially reducing mucus production and inflammatory responses in respiratory diseases.

VX 809

936727-05-8sc-474670
10 mg
$592.00
(0)

Targets the CFTR protein and corrects its folding and trafficking, potentially reducing MUC5AC overproduction and mucus viscosity in cystic fibrosis.

Fisetin

528-48-3sc-276440
sc-276440A
sc-276440B
sc-276440C
sc-276440D
50 mg
100 mg
500 mg
1 g
100 g
$51.00
$77.00
$102.00
$153.00
$2856.00
7
(1)

Modulates MUC5AC expression and secretion, potentially reducing mucus production and inflammatory responses in respiratory diseases through its anti-inflammatory effects.

Geranylgeranylacetone

6809-52-5sc-252851
sc-252851A
10 mg
100 mg
$65.00
$155.00
2
(1)

Exhibits anti-inflammatory and mucoregulatory properties, potentially reducing MUC5AC expression and secretion and attenuating mucus hypersecretion in respiratory conditions.

Itraconazole

84625-61-6sc-205724
sc-205724A
50 mg
100 mg
$76.00
$139.00
23
(1)

May inhibit MUC5AC expression through unknown mechanisms, potentially reducing mucus production in respiratory diseases.