Date published: 2025-10-15

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Scopoletin (CAS 92-61-5)

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Alternate Names:
6-Methoxyumbelliferone
Application:
Scopoletin is a dye used to detect release of reactive oxygen species such as peroxynitrite & inhibits acetylcholinesterase
CAS Number:
92-61-5
Purity:
≥95%
Molecular Weight:
192.17
Molecular Formula:
C10H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dye that can be used to detect the release of reactive oxygen species during the oxidative burst; peroxynitrite scavenger; acetylcholinesterase inhibitor.


Scopoletin (CAS 92-61-5) References

  1. Active components from Artemisia iwayomogi displaying ONOO(-) scavenging activity.  |  Kim, AR., et al. 2004. Phytother Res. 18: 1-7. PMID: 14750192
  2. The scopoletin assay for hydrogen peroxide. A review and a better method.  |  Corbett, JT. 1989. J Biochem Biophys Methods. 18: 297-307. PMID: 2674266
  3. Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice.  |  Choi, RY., et al. 2017. Phytother Res. 31: 1795-1804. PMID: 28921708
  4. Scopoletin Stimulates Melanogenesis via cAMP/PKA Pathway and Partially p38 Activation.  |  Kim, DS., et al. 2017. Biol Pharm Bull. 40: 2068-2074. PMID: 28943528
  5. Scopoletin inhibits α-glucosidase in vitro and alleviates postprandial hyperglycemia in mice with diabetes.  |  Jang, JH., et al. 2018. Eur J Pharmacol. 834: 152-156. PMID: 30031794
  6. Acaricidal Mechanism of Scopoletin Against Tetranychus cinnabarinus.  |  Zhou, H., et al. 2019. Front Physiol. 10: 164. PMID: 30894818
  7. Novel Scopoletin Derivatives Kill Cancer Cells by Inducing Mitochondrial Depolarization and Apoptosis.  |  Shi, Z., et al. 2021. Anticancer Agents Med Chem. 21: 1774-1782. PMID: 33292145
  8. Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer.  |  Yuan, C., et al. 2021. Life Sci. 270: 119105. PMID: 33497736
  9. Scopoletin Attenuates Intracerebral Hemorrhage-Induced Brain Injury and Improves Neurological Performance in Rats.  |  Zhang, W., et al. 2021. Neuroimmunomodulation. 28: 74-81. PMID: 33744895
  10. Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of Scopoletin.  |  Sakthivel, KM., et al. 2022. J Pharm Pharmacol. 74: 147-161. PMID: 33847360
  11. Scopoletin inhibits PDGF-BB-induced proliferation and migration of airway smooth muscle cells by regulating NF-κB signaling pathway.  |  Fan, Z., et al. 2022. Allergol Immunopathol (Madr). 50: 92-98. PMID: 34965643
  12. Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress.  |  Wu, Z., et al. 2022. Toxicol Appl Pharmacol. 436: 115858. PMID: 34979142
  13. Scopoletin stimulates the secretion of insulin via a KATP channel-dependent pathway in INS-1 pancreatic β cells.  |  Park, JE., et al. 2022. J Pharm Pharmacol. 74: 1274-1281. PMID: 35099527
  14. Scopoletin: a review of its source, biosynthesis, methods of extraction, and pharmacological activities.  |  Antika, LD., et al. 2022. Z Naturforsch C J Biosci. 77: 303-316. PMID: 35218175
  15. Scopoletin Induced Metabolomic Profile Disturbances in Zebrafish Embryos.  |  Yao, W., et al. 2022. Metabolites. 12: PMID: 36295836

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Scopoletin, 50 mg

sc-206059
50 mg
$97.00

Scopoletin, 100 mg

sc-206059A
100 mg
$178.00