Scopoletin CAS: 92-61-5
MF: C10H8O4
MW: 192.17
A dye used to detect release of reactive oxygen species such as peroxynitrite & inhibits acetylcholinesterase.

Scopoletin (CAS 92-61-5)

Scopoletin | CAS 92-61-5 is rated 5.0 out of 5 by 1.
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Alternate Names: 6-Methoxyumbelliferone
Application: Scopoletin is a dye used to detect release of reactive oxygen species such as peroxynitrite & inhibits acetylcholinesterase
CAS Number: 92-61-5
Purity: ≥98%
Molecular Weight: 192.17
Molecular Formula: C10H8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Scopoletin is a dye that can be used to detect the release of reactive oxygen species during the oxidative burst, peroxynitrite scavenger and AChE(acetylcholinesterase) inhibitor.


References

1. Suzuki, Y., et al. 2003. J. Immunol. 171: 6119-6127. PMID: 14634127
2. Kim, A.R., et al. 2004. Phytother Res. 18: 1-7. PMID: 14750192
3. Lee, J.H., et al. 2004. Arch. Pharm. Res. 27: 53-56. PMID: 14969339

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (partly), hot alcohol, hot glacial acetic acid, chloroform (moderately), and methanol (sparingly).
Storage :
Store at room temperature
Melting Point :
203-205° C
Boiling Point :
~413.5° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Aldose reductase: IC50 = 74.4 µM (human); Cox-2: IC50 >100uM µM (human); Sorbitol dehydrogenase: IC50 = 137 µM (human); AChE: IC50 = 168.6 µM (human); 15-LO : IC50 = 16.5 uM (European rabbit)
Ki Data :
CA IX: Ki= 0.96 µM (human); CA XII: Ki= 4.05 µM (human); CA VII: Ki= 8.71 µM (human); CA I: Ki= 10.56 µM (human); CA XIII: Ki= 17.8 µM (human)
pK Values :
pKa: 7.91 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
GN6930000
PubChem CID :
5280460
Merck Index :
14: 8408
MDL Number :
MFCD00006872
EC Number :
202-171-9
Beilstein Registry :
156296
SMILES :
COC1=C(C=C2C(=C1)C=CC(=O)O2)O

Download SDS (MSDS)

Certificate of Analysis

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Scopoletin (CAS 92-61-5)  Product Citations

See how others have used Scopoletin (CAS 92-61-5). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 18024545  de Cavanagh, EM. et al. 2008. Am. J. Physiol. Heart Circ. Physiol. 294: H456-H465.

PMID: # 9632805  Kiefer, F. et al. 1998. Mol. Cell. Biol. 18: 4209-4220.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from The use of scopoletin as a dye to detect The use of scopoletin as a dye to detect the release of reactive oxygen species and as an inhibitor of acetylcholinerase is cited in various publications. -SCBT Publication Review
Date published: 2015-03-19
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