Mucin 10 Inhibitors
Chemical inhibitors of Mucin 10 can disrupt its function by targeting the various stages of its glycosylation process. Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside and 2-Deoxy-D-glucose are two such inhibitors that interfere with the initial stages of glycosylation. Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside mimics the structure of natural substrates, thereby inhibiting the enzymes that attach sugar moieties to Mucin 10. On the other hand, 2-Deoxy-D-glucose competes with glucose, which is an essential sugar necessary for the glycosylation of proteins. The correct attachment of glucose is crucial for the subsequent addition of other sugars; hence, its inhibition can impede the proper maturation of Mucin 10. Tunicamycin takes a different approach by blocking the transfer of N-acetylglucosamine to dolichol monophosphate, a lipid carrier molecule that is key in the N-linked glycosylation pathway. This blockage can halt the glycosylation process, leading to the functional inhibition of Mucin 10.
Another set of inhibitors, such as Swainsonine and Castanospermine, target specific enzymes involved in the trimming and processing of the glycan structures attached to Mucin 10. Swainsonine inhibits mannosidase II, which is involved in the processing of N-glycans, while Castanospermine inhibits glucosidases that are responsible for trimming glucose residues in the N-linked glycosylation pathway. Kifunensine and Deoxymannojirimycin both act on mannosidase enzymes; Kifunensine inhibits mannosidase I, and Deoxymannojirimycin targets mannosidases more broadly, which are necessary for the proper formation of the glycan structures on Mucin 10. Deoxynojirimycin, similarly to Castanospermine, inhibits glucosidase enzymes, further preventing the correct glycosylation of Mucin 10. Brefeldin A and Monensin disrupt the Golgi apparatus, where the glycosylation and processing of Mucin 10 are finalized. Brefeldin A disassembles the Golgi structure, and Monensin alters Golgi pH, both leading to a functional inhibition of Mucin 10 due to improper glycosylation and processing. Finally, NB-DNJ (N-butyldeoxynojirimycin) and Nojirimycin each target glucosidase and hexosaminidase, respectively, enzymes that are crucial for the final maturation and proper function of the glycoprotein structure of Mucin 10.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside | 3554-93-6 | sc-203427 sc-203427A | 100 mg 1 g | $350.00 $3184.00 | 2 | |
This chemical specifically inhibits the glycosylation process by mimicking the structure of the substrates used by Mucin 10 in glycosylation. Inhibition of glycosylation can impair the proper functioning and stability of Mucin 10. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
This glucose analog inhibits glycosylation by competing with glucose, which is necessary for the glycosylation process that Mucin 10 undergoes. Disruption of this process can inhibit the maturation and function of Mucin 10. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation by blocking the transfer of N-acetylglucosamine to dolichol monophosphate, which is a crucial step in the glycosylation process involving Mucin 10, thereby functionally inhibiting Mucin 10. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Swainsonine inhibits mannosidase II, an enzyme involved in the processing of N-glycans. Since Mucin 10 undergoes glycosylation, inhibition of this enzyme can result in the functional inhibition of Mucin 10 due to improper glycan processing. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
Castanospermine inhibits glucosidases, which are enzymes involved in the trimming of glucose residues in N-linked glycosylation. This inhibition can result in the functional inhibition of Mucin 10 through the disruption of proper glycosylation. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $135.00 $540.00 $1025.00 $6248.00 | 25 | |
Kifunensine specifically inhibits mannosidase I, an enzyme in the N-glycosylation pathway. As Mucin 10 requires proper glycosylation to function, the inhibition of this enzyme can lead to the functional inhibition of Mucin 10. | ||||||
Deoxymannojirimycin hydrochloride | 84444-90-6 | sc-201360 sc-201360A | 1 mg 5 mg | $93.00 $239.00 | 2 | |
Deoxymannojirimycin inhibits mannosidase, which is necessary for the trimming of mannose residues in the N-glycan maturation process. Inhibiting this process can lead to the functional inhibition of Mucin 10 through improper glycan formation. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
Deoxynojirimycin inhibits glucosidase enzymes involved in the N-glycosylation process, which is essential for the proper function of Mucin 10. Inhibiting these enzymes can lead to the functional inhibition of Mucin 10 by preventing correct glycosylation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus, where glycosylation of proteins like Mucin 10 takes place. This disruption can lead to the functional inhibition of Mucin 10 by preventing its proper glycosylation and subsequent trafficking to the cell membrane. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin disrupts Golgi function, which is essential for the glycosylation and processing of Mucin 10. By disrupting the Golgi apparatus, monensin can functionally inhibit Mucin 10 by impairing its maturation and glycosylation. | ||||||