MT-MMP-4 Activators
The chemical class known as MT-MMP-4 Activators encompasses a range of compounds that indirectly influence the activity of membrane-type matrix metalloproteinase 4 (MT-MMP-4), a protein playing a crucial role in extracellular matrix remodeling and cellular processes. These activators operate through various cellular signaling pathways and mechanisms, highlighting the intricate web of biological interactions where MT-MMP-4 functions. Key members of this class include Forskolin and Ionomycin, which modulate levels of intracellular second messengers like cyclic AMP (cAMP) and calcium, respectively. The elevation of cAMP by Forskolin, achieved through the activation of adenylate cyclase, can lead to changes in cellular activities that indirectly affect MT-MMP-4 function. Ionomycin, on the other hand, facilitates an influx of calcium ions, triggering a cascade of events within calcium-dependent signaling pathways that can influence the activity of MT-MMP-4. These indirect modulations underscore the sensitivity of MT-MMP-4 to the broader cellular environment and its regulatory mechanisms.
Furthermore, this chemical class includes compounds like PMA (Phorbol 12-myristate 13-acetate) and growth factors like EGF (Epidermal Growth Factor) and TGF-beta (Transforming Growth Factor-beta). PMA functions as a potent activator of protein kinase C (PKC), a key player in various signaling pathways, which can indirectly affect MT-MMP-4's role in cellular processes. Growth factors such as EGF and TGF-beta, while primarily involved in cell growth and differentiation, can also impact the expression and activity of MT-MMP-4 through their respective receptor-mediated signaling pathways. These interactions highlight the complex regulatory network surrounding MT-MMP-4, where external signals and intracellular messengers converge to modulate its activity. The diversity of this chemical class reflects the multifaceted nature of cellular signaling and the nuanced ways in which MT-MMP-4 can be regulated within the cellular milieu, emphasizing the protein's role in a variety of biological contexts and its responsiveness to a broad spectrum of molecular cues.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
A broad-spectrum MMP inhibitor that can indirectly increase MT-MMP 4 activity by blocking the activity of competing MMPs, thereby allowing MT-MMP 4 to have a more prominent role in matrix degradation processes it is involved in. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Another broad-spectrum MMP inhibitor that, similar to Batimastat, can reduce the activity of other MMPs to indirectly enhance the substrate availability and functional prominence of MT-MMP 4. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which can enhance MT-MMP-4 activity through cAMP-dependent pathways. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
An MMP inhibitor which can potentially increase MT-MMP 4 activity by reducing competition for substrates, enabling MT-MMP 4 to function more effectively in its unique roles such as modulating cell surface behavior. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
While known as an antibiotic, Doxycycline also acts as an inhibitor of MMPs and could indirectly enhance MT-MMP 4 activity by decreasing the activity of other MMPs in the extracellular matrix, thus spotlighting MT-MMP 4′s actions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activates protein kinase C, which can modulate MT-MMP-4 activity through phosphorylation processes. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
By increasing the availability of calcium ions, Calcium chloride can potentially enhance the activity of MT-MMP 4, as calcium ions play a role in the regulation and stability of MMPs. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions are crucial cofactors for MMPs, and by supplementing Zinc, Zinc sulfate could potentially enhance the catalytic activity of MT-MMP 4. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Elevates intracellular calcium, potentially affecting MT-MMP-4 activity through calcium signaling pathways. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Can modulate MT-MMP-4 activity indirectly by interacting with growth factors and extracellular matrix. | ||||||