MSR Activators
The chemical class termed MSR Activators encompasses a range of compounds that can enhance the activity of the enzyme Methionine Synthase Reductase (MSR). This class is characterized by its ability to modulate various biochemical pathways that intersect with the function of MSR, contributing to the maintenance and efficient functioning of methionine synthesis and the wider methylation cycle. The activation of MSR by these compounds is achieved through the optimization of substrate availability, cofactor interaction, and stabilization of the enzyme, as well as through the modulation of associated metabolic pathways. These activators ensure that MSR is provided with the necessary constituents to perform its catalytic role in the regeneration of methionine from homocysteine, a process that is essential for maintaining homocysteine levels within a normal range and for the production of S-adenosylmethionine, a critical methyl donor in numerous methylation reactions within the cell.
Within this chemical class, compounds can also act by influencing the cellular redox state, thus indirectly supporting the reductive activation cycle of MSR. The importance of this class lies in its ability to facilitate the electron transfer processes that are vital for MSR's function. By maintaining the reduced state of cofactors and the enzyme itself, these activators can assure that MSR operates at its optimal capacity. Furthermore, these compounds can enhance MSR activity by promoting the stabilization of enzyme structure and enzyme-cofactor interactions, which are critical for MSR's activity. Collectively, these activators play a pivotal role in the upkeep of a functional methionine cycle, ensuring that methionine regeneration proceeds efficiently, which in turn supports a myriad of methylation-dependent cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
SAMe is a cosubstrate involved in methyl group transfers. By donating methyl groups and facilitating the remethylation process that MSR is a part of, SAMe could possibly activate MSR by ensuring a continuous supply of methionine. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid is a precursor in the production of tetrahydrofolate (THF). An increase in THF could possibly activate MSR by enhancing the availability of substrates for the folate cycle and methionine regeneration. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Cobalamin is a necessary cofactor for MSR, required for the reactivation of methionine synthase. Ensuring adequate levels of cobalamin could possibly activate MSR by maintaining the enzyme in a functional state. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine donates a methyl group to homocysteine to form methionine. This donation could possibly activate MSR by reducing the homocysteine load and supporting the methionine cycle. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
Riboflavin is essential for the production of FAD and FMN, involved in redox reactions. Adequate riboflavin could possibly activate MSR by maintaining reduced flavoproteins necessary for MSR function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc stabilizes protein structures and acts as a cofactor for enzymes. Zinc could possibly activate MSR by enhancing the stability of MSR and its interaction with methionine synthase. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $102.00 | ||
Pyridoxal phosphate is a cofactor for amino acid metabolism enzymes. Adequate levels could possibly activate MSR by improving the metabolism of homocysteine and supporting the methionine cycle. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine levels could possibly activate MSR by feedback-regulating homocysteine levels and thus influencing the methionine cycle in which MSR operates. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $27.00 $77.00 | 2 | |
Creatine could possibly activate MSR by influencing SAMe consumption for its synthesis, which may help balance SAMe levels and support MSR activity within the methionine cycle. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
NAC could possibly activate MSR by providing cysteine for glutathione, affecting the cellular redox state, which, in turn, may impact the oxidation state of methionine synthase's cobalamin cofactor and MSR activity. | ||||||