MSH3_Msh3 Activators
MSH3 activators, as listed, are primarily chemicals that indirectly affect MSH3 activity by inducing DNA damage or stress, thereby potentially enhancing DNA mismatch repair processes in which MSH3 is involved. MSH3, being a key component of the mismatch repair system, is critical for correcting base-base mismatches and insertion-deletion loops that arise during DNA replication and after damage. The chemicals listed, such as platinum-based compounds (cisplatin, oxaliplatin), alkylating agents (MNNG), topoisomerase inhibitors (camptothecin, etoposide), and others, induce various forms of DNA damage, thereby potentially increasing the cellular demand for MSH3-mediated repair.
The significance of these activators lies in their ability to challenge and potentially enhance the DNA repair machinery. For instance, agents like 5-fluorouracil and doxorubicin, widely used in chemotherapy, induce DNA lesions that can stimulate the DNA repair pathways, including the one involving MSH3. Similarly, radiation (UV and gamma) is known to cause extensive DNA damage, leading to increased activity of DNA repair proteins.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil induces DNA damage, potentially increasing the demand for DNA repair mechanisms, including MSH3-mediated mismatch repair. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin causes DNA crosslinking, leading to enhanced activation of DNA repair pathways, possibly affecting MSH3 function. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $112.00 $394.00 | 8 | |
Oxaliplatin, similar to cisplatin, induces DNA crosslinking and may stimulate DNA repair systems involving MSH3. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea induces replication stress, which could lead to the activation of DNA repair pathways, including those involving MSH3. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, causing DNA damage and possibly enhancing MSH3-mediated repair activities. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, leading to DNA breaks and potentially increased activity of MSH3-related repair pathways. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin induces DNA breaks and can stimulate DNA repair mechanisms, possibly involving MSH3. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Bleomycin causes DNA strand breaks, potentially increasing the activity of DNA repair pathways, including MSH3. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
ATR inhibitor VE-821 induces replication stress, which might enhance the activity of MSH3 as part of the DNA repair response. | ||||||