MS4A8B Inhibitors
MS4A8B inhibitors are chemicals that interact with and modulate various cellular signaling pathways, leading to the inhibition of MS4A8B activity. LY294002, for example, is a potent inhibitor of the PI3K, pivotal in the PI3K/AKT signaling pathway. By preventing AKT activation, LY294002 indirectly inhibits the downstream effects on MS4A8B, which relies on AKT phosphorylation for activation. Wortmannin, another PI3K inhibitor, similarly impedes the PI3K/AKT/mTOR signaling, a pathway known to impact MS4A8B's activity. The irreversible nature of Wortmannin's inhibition suggests a consistent suppression of MS4A8B activity in the presence of this compound.
Rapamycin, Torin 1, PP242, and AZD8055 are all inhibitors that target mTOR, a kinase involved in cell growth and metabolism that is also implicated in the regulation of MS4A8B. By selectively inhibiting mTORC1 and mTORC2, these compounds diminish the phosphorylation and activation of downstream proteins that are part of the mTOR signaling network, ultimately leading to a decrease in MS4A8B activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A specific inhibitor of phosphatidylinositol 3-kinase (PI3K). LY294002 prevents the phosphorylation and activation of AKT, which is critical for the PI3K/AKT pathway. Since MS4A8B is a downstream target in this pathway, its activity is inhibited when AKT is not phosphorylated and activated. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
An irreversible inhibitor of PI3K, Wortmannin suppresses the PI3K/AKT/mTOR pathway, leading to reduced phosphorylation of downstream targets including MS4A8B, thus inhibiting its activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that specifically binds to FKBP12 and inhibits mTORC1. MS4A8B, which is a protein downstream of the mTOR pathway, can have its activity reduced due to the suppression of mTORC1-mediated signaling. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
A selective ATP-competitive mTOR inhibitor that inhibits both mTORC1 and mTORC2. MS4A8B is affected by the inhibition of these complexes, interfering with downstream signaling that regulates its function. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
A selective inhibitor of mTOR kinase that affects both mTORC1 and mTORC2. Its inhibition of mTOR signaling can lead to decreased activity of MS4A8B due to the disruption of downstream effects. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
An ATP-competitive inhibitor of mTOR kinase, inhibiting both mTORC1 and mTORC2. The action of AZD8055 results in inhibition of downstream targets in the mTOR pathway, including MS4A8B. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An inhibitor of MEK1/2 that blocks the MAPK/ERK pathway. PD98059's inhibition of MEK leads to decreased activation and function of downstream proteins, potentially including MS4A8B. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A selective inhibitor of p38 MAPK. Inhibition of p38 MAPK can lead to a reduction in the activity of proteins like MS4A8B that may be regulated by stress-activated pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of c-Jun N-terminal kinase (JNK), leading to decreased activity of transcription factors regulated by JNK, which may include factors controlling MS4A8B function. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $179.00 $700.00 | 9 | |
A specific inhibitor of p70 S6 kinase 1 (S6K1). As S6K1 is downstream of mTORC1, PF-4708671's inhibition can lead to reduced signaling to downstream proteins such as MS4A8B. | ||||||