MS4A8B Antibody (B-6): sc-515138

MS4A8B Antibody (B-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects MS4A8B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-MS4A8B antibody (B-6) is available as a non-conjugated format. MS4A8B, also known as four-span transmembrane protein 4, is a 250 amino acid multi-pass membrane protein predominantly expressed in hematopoietic cells and tissues. MS4A8B belongs to the membrane-spanning 4-domain family, subfamily A, which consists of at least 26 members in both mouse and human species. MS4A8B structure, characterized by four highly conserved transmembrane domains flanked by amino- and carboxyl-cytoplasmic regions, is crucial for function in cell signaling and immune response regulation. The gene encoding MS4A8B is located on human chromosome 11, a region associated with various genetic disorders, including Jervell and Lange-Nielsen syndrome and Smith-Lemli-Opitz syndrome, highlighting MS4A8B importance in maintaining cellular homeostasis and potential implications in disease pathology.

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MS4A8B Antibody (B-6) References:

1. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.  |  Ishibashi, K., et al. 2001. Gene. 264: 87-93. PMID: 11245982
2. Hereditary angioedema. Long-term follow-up of 88 patients. Experience of the Argentine Allergy and Immunology Institute.  |  Fabiani, JE., et al. 2000. Allergol Immunopathol (Madr). 28: 267-71. PMID: 11270087
3. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse.  |  Liang, Y. and Tedder, TF. 2001. Genomics. 72: 119-27. PMID: 11401424
4. Structural organization of the human MS4A gene cluster on Chromosome 11q12.  |  Liang, Y., et al. 2001. Immunogenetics. 53: 357-68. PMID: 11486273
5. Smith-Lemli-Opitz syndrome and the DHCR7 gene.  |  Jira, PE., et al. 2003. Ann Hum Genet. 67: 269-80. PMID: 12914579
6. The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease.  |  Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
7. Jervell and Lange-Nielsen syndrome in Norwegian children: aspects around cochlear implantation, hearing, and balance.  |  Siem, G., et al. 2008. Ear Hear. 29: 261-9. PMID: 18595190
8. Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome).  |  Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
9. An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome.  |  Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MS4A8B Antibody (B-6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MS4A8B Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MS4A8B Antibody (B-6) Specifications

Alternate Product Name: MS4A8B

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-76

Epitope Target: MS4A8B

Epitope Species: human

Product Reactivity/Detection: MS4A8B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MS4A8B Antibody (B-6): N/A