MRP3 Activators
MRP3 Activators belong to a specialized category of chemical compounds designed to modulate the activity of the multidrug resistance-associated protein 3 (MRP3). MRP3 is a member of the ATP-binding cassette (ABC) transporter superfamily, a group of transmembrane proteins that play a pivotal role in drug and xenobiotic disposition within the body. Specifically, MRP3 is involved in the transport of various endogenous and exogenous compounds, including drugs, metabolites, and conjugated organic anions, across cell membranes. Its presence is notable in several tissues, particularly in the liver and intestine, where it contributes to the elimination of harmful substances from the body.
MRP3 Activators are compounds designed to interact with MRP3 and modulate its transport function. These activators can either enhance or inhibit the transport activity of MRP3, depending on their chemical structure and mode of action. By targeting MRP3, these compounds may influence the efflux of a wide range of substrates, impacting drug pharmacokinetics, xenobiotic detoxification, and the maintenance of cellular homeostasis. The study of MRP3 Activators is vital for advancing our understanding of drug disposition, xenobiotic metabolism, and cellular detoxification processes, as well as for exploring strategies to modulate MRP3-mediated transport in different tissues and under various physiological conditions. Researchers continue to investigate the precise mechanisms of MRP3 activation and its implications in drug metabolism and cellular physiology, offering insights into the complex interplay between ABC transporters and their substrates.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
Indomethacin has been shown to activate MRP3 by increasing its expression and transport activity. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin enhances MRP3 activity by upregulating its expression, likely through activation of pregnane X receptor (PXR) which regulates MRP3 gene expression. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz has been found to induce MRP3 expression, possibly through Nrf2-mediated signaling pathways. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $37.00 | 13 | |
Chrysin is a flavonoid that activates MRP3 by enhancing its expression, potentially through modulation of PXR and CAR. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane, a compound found in cruciferous vegetables, upregulates MRP3 expression, likely via Nrf2 pathway activation. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
This thiazolidinedione activates MRP3 by upregulating its expression, likely involving peroxisome proliferator-activated receptor gamma (PPARγ) activation. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $66.00 | 4 | |
tBHQ, an antioxidant, can activate MRP3 by enhancing its expression, likely through the Nrf2 signaling pathway. | ||||||