Date published: 2025-10-25

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MRP2 Inhibitors

MRP2 inhibitors constitute a class of compounds designed to selectively modulate the activity of the multidrug resistance-associated protein 2 (MRP2). MRP2 is a membrane transporter protein that plays a crucial role in the cellular efflux of various endogenous and exogenous compounds, including drugs and toxic metabolites. By inhibiting MRP2, these compounds aim to interfere with its function as a transporter, altering the cellular distribution and elimination of its substrate molecules. MRP2 is predominantly found in the apical membrane of epithelial cells in tissues such as the liver, intestine, and kidney, where it contributes to the excretion of waste products and xenobiotics. Research into MRP2 inhibitors seeks to elucidate the intricate mechanisms underlying the transport of various molecules by MRP2. These inhibitors provide valuable tools to investigate how the modulation of MRP2 function impacts the disposition of substrates in various tissues and organs. Furthermore, the study of MRP2 inhibitors aids in understanding drug-drug interactions and pharmacokinetic alterations resulting from the inhibition of this transporter. Insights gained from the exploration of MRP2 inhibitors have broader implications in drug development, toxicology, and the understanding of how cellular efflux mechanisms contribute to the overall homeostasis of the body.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$62.00
$90.00
$299.00
$475.00
$1015.00
$2099.00
69
(5)

Interferes with MRP2 transport by interacting with the transporter's substrate-binding site.

Glyburide (Glibenclamide)

10238-21-8sc-200982
sc-200982A
sc-200982D
sc-200982B
sc-200982C
1 g
5 g
25 g
100 g
500 g
$45.00
$60.00
$115.00
$170.00
$520.00
36
(1)

Competes with endogenous substrates for MRP2 binding, reducing its activity.

Probenecid

57-66-9sc-202773
sc-202773A
sc-202773B
sc-202773C
1 g
5 g
25 g
100 g
$27.00
$38.00
$98.00
$272.00
28
(2)

General inhibitor of organic anion transporters, including MRP2, by competing with substrates.

Indomethacin

53-86-1sc-200503
sc-200503A
1 g
5 g
$28.00
$37.00
18
(1)

Inhibits MRP2 activity by interfering with the transport of substrates by the transporter.

Probucol

23288-49-5sc-203666
sc-203666A
100 mg
1 g
$77.00
$163.00
5
(1)

Interacts with MRP2's substrate-binding site, impacting the transport of various compounds.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$108.00
$245.00
$918.00
$49.00
33
(2)

Inhibits MRP2-mediated transport, possibly by interfering with transporter function and expression.

Erythromycin

114-07-8sc-204742
sc-204742A
sc-204742B
sc-204742C
5 g
25 g
100 g
1 kg
$56.00
$240.00
$815.00
$1305.00
4
(3)

Suggested to inhibit MRP2 function, possibly through interference with transporter-mediated efflux.