MRI1 Activators
MRI1 include a range of substances that provide either the necessary cofactors for the enzyme's activity or the substrates required for its methylation reactions. ATP is central to the activation of MRI1, serving as a source of phosphate groups and the energy necessary for the methylation process. The presence of ATP is crucial, as it binds to MRI1 and facilitates the transfer of methyl groups onto specific substrates. Similarly, magnesium ions are vital for MRI1 function, as they form complexes with ATP, thus enhancing the stability and proper orientation of ATP within the active site of MRI1, which is a prerequisite for effective catalysis.
MRI1 relies on S-Adenosylmethionine (SAM) as a methyl group donor to carry out methylation. SAM's role is to provide the methyl group that MRI1 transfers to its substrates. The synthesis of SAM itself is supported by folate and cobalamin, which are involved in one-carbon metabolism and the methionine cycle, respectively. This process is also supported by methionine, choline, and betaine, each contributing to the generation of SAM and, consequently, the methylation capacity of MRI1. Zinc ions can be important for the structural integrity of MRI1, potentially influencing the enzyme's ability to interact with its substrates and cofactors effectively. Inositol may play a role in maintaining SAM concentrations, thus indirectly influencing MRI1 activity. NAD+ and riboflavin contribute to the production of ATP within the cell, thereby supporting the overall energy balance necessary for MRI1's methylation activity to proceed. Collectively, these chemical activators are integral to the proper functioning of MRI1, ensuring that it can perform its role in cellular methylation processes.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP, as the primary energy currency of the cell, is crucial for the energy-dependent catalytic activities of MRI1. As MRI1 is involved in methylation reactions, ATP can provide the necessary phosphate groups and energy for the methylation process, thereby activating MRI1's enzymatic function. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $180.00 $655.00 | 2 | |
SAM serves as a methyl donor in a variety of methylation reactions catalyzed by methyltransferases, including MRI1. The provision of a methyl group by SAM is essential for MRI1's catalytic action in methylation, directly enhancing its function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can act as a structural or catalytic cofactor for many enzymes. In the case of MRI1, Zn2+ may stabilize the three-dimensional structure of the protein, enhancing its enzymatic activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $72.00 | 2 | |
Folic acid is involved in the generation of SAM through one-carbon metabolism. By increasing the availability of SAM, folic acid indirectly supports the methylation reactions catalyzed by MRI1. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $39.00 $55.00 $204.00 $877.00 $3414.00 $9180.00 | 2 | |
Cobalamin is essential for the proper functioning of the methionine synthase reaction, which is involved in the regeneration of SAM. Adequate levels of vitamin B12 thus indirectly support the methylation activity of MRI1 by ensuring a consistent supply of SAM. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $36.00 $56.00 $148.00 $566.00 $1081.00 | ||
Methionine is a precursor in the synthesis of SAM. Increased availability of methionine can boost the levels of SAM, subsequently enhancing the methyltransferase activity of MRI1. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $32.00 $36.00 $51.00 | 1 | |
Choline can be oxidized to betaine, which is then involved in the methionine cycle leading to the production of SAM. By contributing to SAM synthesis, choline indirectly supports MRI1's methyltransferase function. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $30.00 $40.00 $55.00 $160.00 $330.00 $580.00 | 2 | |
Betaine serves as a methyl donor in the conversion of homocysteine to methionine, which is subsequently used to generate SAM. This can increase the methylation capacity of MRI1 by providing more SAM. | ||||||
myo-Inositol | 87-89-8 | sc-202714 sc-202714A sc-202714B sc-202714C | 100 g 250 g 1 kg 5 kg | $78.00 $148.00 $270.00 $821.00 | ||
Inositol might play a role in the regulation of SAM concentrations within the cell. By influencing the levels of SAM, inositol could indirectly enhance the methyltransferase activity of MRI1. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
NAD+ is involved in the synthesis of ATP through cellular respiration. An increase in ATP levels can heighten the catalytic efficiency of MRI1, which requires ATP for methylation reactions. | ||||||