Mps1 Activators
Mps1 (Monopolar spindle 1), also known as TTK, is a protein kinase crucial for ensuring accurate chromosome segregation during cell division. It is a core component of the spindle assembly checkpoint (SAC), a surveillance mechanism that blocks cells from dividing until all chromosomes are properly attached to the mitotic spindle.Mps1 functions primarily by phosphorylating various target proteins involved in the SAC, including kinetochore proteins, thereby controlling the attachment of the spindle microtubules to the kinetochores (structures on chromosomes where the spindle fibers attach during cell division). If chromosomes are not correctly attached, Mps1 inhibits the cell from progressing into anaphase, the stage of cell division where the chromosomes are separated.
Mps1 is also involved in the centrosome duplication cycle. It plays a role in initiating centrosome replication and inhibits overduplication, thus ensuring cells have the correct number of centrosomes.Aberrant Mps1 function can lead to chromosomal instability, a hallmark of many cancers. Overexpression of Mps1 has been observed in various types of cancer, including breast, lung, and colorectal cancers. Due to its role in cell division and its association with cancer, Mps1 has become a potential target for cancer. Despite our current understanding, the complete range of Mps1's biological functions and its implications in disease remain an active area of research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules, potentially affecting spindle checkpoint functions and indirectly influencing Mps1 activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole, a microtubule-depolymerizing agent, can disrupt spindle formation, possibly impacting Mps1-related pathways. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $147.00 $1029.00 $1632.00 $3264.00 $4296.00 | 1 | |
BI 2536, a Plk1 inhibitor, can disrupt mitotic progression, potentially affecting Mps1's role in checkpoint regulation. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439, an Aurora kinase inhibitor, affects mitotic spindle dynamics, potentially influencing Mps1 activity. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-FU, a pyrimidine analog, interferes with DNA synthesis and repair, potentially impacting Mps1 activity in cell cycle control. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
Purvalanol A, a cyclin-dependent kinase inhibitor, can affect cell cycle progression, potentially impacting Mps1 function. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $61.00 $85.00 | 4 | |
VX-680, an inhibitor of Aurora kinases, may indirectly influence Mps1 activity by affecting mitotic spindle checkpoints. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933, an ATM kinase inhibitor, can influence DNA damage response, potentially affecting Mps1's role in cell cycle regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, might have an indirect impact on Mps1 activity through its role in signaling pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can affect various cellular processes, potentially influencing Mps1 activity. | ||||||