MP19 Inhibitors
MP19 inhibitors are a class of chemical compounds designed to specifically target and inhibit the function of MP19, a protein involved in the structure and function of the lens in the eye. MP19, also known as Lens Membrane Protein 19, is a key component of the lens fiber cells, which are essential for maintaining lens transparency and the proper refraction of light. MP19 is embedded in the plasma membrane of lens fiber cells, contributing to the structural integrity of the lens and facilitating the cellular interactions necessary for maintaining a tightly packed, highly organized arrangement of lens fibers. By inhibiting MP19, researchers can disrupt these structural and cellular processes, providing a tool to study the specific role of MP19 in lens biology, cell-cell adhesion, and overall lens homeostasis.
In research settings, MP19 inhibitors are valuable for investigating the molecular mechanisms that underlie lens transparency and the role of membrane proteins in maintaining the highly specialized cellular environment of the eye's lens. By blocking MP19 function, scientists can examine how the disruption of this protein affects the organization of lens fibers, the stability of cell junctions, and the overall clarity of the lens. This inhibition allows researchers to study downstream effects such as changes in lens cell morphology, alterations in protein interactions within the lens membrane, and potential impacts on the biomechanical properties of the lens. Additionally, MP19 inhibitors provide insights into the interactions between MP19 and other lens-specific proteins, helping to elucidate the complex network of factors that contribute to lens structure, cellular adhesion, and light transmission. Through these studies, MP19 inhibitors enhance our understanding of the critical role of membrane proteins in lens physiology and the broader implications of protein regulation in maintaining the structural integrity and function of the eye.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
As a sodium channel blocker, Amiloride can inhibit sodium-dependent processes in lens fiber cells. Given that MP19 has been implicated in maintaining lens transparency possibly by controlling ion balance, Amiloride can indirectly affect its functional role by altering sodium ion homeostasis within the cell. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP can potentially affect downstream signaling pathways that MP19 is speculated to be a part of, in terms of ion channel regulation or cellular adhesion within the lens, thereby serving as an indirect inhibitor. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil acts as a calcium channel blocker and can inhibit calcium-dependent cellular mechanisms. Considering MP19's potential involvement in ion channel regulation or modulation within lens cells, Verapamil can act as an indirect inhibitor by disrupting calcium ion balance. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a Rho-associated kinase (ROCK) inhibitor that can influence the dynamics of the cytoskeleton and cell shape. Given that MP19 might play a role in maintaining lens cell shape by stabilizing the membrane-cytoskeleton interface, Y-27632 can serve as an indirect inhibitor. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is an inositol trisphosphate (IP3) receptor inhibitor that disrupts calcium signaling. By doing so, it may indirectly affect protein-protein interactions or ion channel modulations that MP19 could be involved in, thereby acting as an indirect inhibitor. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a Na+/K+-ATPase inhibitor affecting ion homeostasis within lens fiber cells. Given MP19's implicated role in maintaining ion balance, Ouabain can indirectly affect MP19 function by disrupting Na+/K+ gradients essential for cellular function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore and disrupts calcium ion gradients within cells. The disruption of calcium balance can potentially affect various cellular processes, including ion channel regulation or modulation, in which MP19 might be involved, thereby acting as an indirect inhibitor. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a protein kinase C (PKC) inhibitor that can alter kinase-mediated signaling pathways. Given that MP19 may be involved in or affected by such pathways, particularly in the context of cellular adhesion or ion channel regulation, Staurosporine can serve as an indirect inhibitor. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can inhibit pathways that involve phosphorylation of proteins. This can affect MP19's potential role in signaling pathways related to cellular adhesion or ion channel modulation within lens cells, thereby acting as an indirect inhibitor. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is an L-type calcium channel inhibitor that alters intracellular calcium levels. Given that MP19 may be involved in calcium-dependent processes or signaling within lens cells, Nifedipine can indirectly inhibit MP19 by disrupting calcium homeostasis. | ||||||