MOSPD3 Activators
MOSPD3 Activators are a diverse array of chemical compounds that target various biochemical pathways to enhance the functional activity of MOSPD3. For instance, Forskolin and 8-Bromo-cAMP function by increasing intracellular cAMP levels, thereby activating PKA, which is known to phosphorylate various substrates. This activation can lead to changes in cellular processes such as cytoskeletal dynamics and motility, potentially enhancing the activity of MOSPD3 in these contexts. Similarly, PMA, a PKC activator, and Bisindolylmaleimide I, a PKC inhibitor, modulate PKC signaling, which is implicated in the regulation of cell motility and organization. The modulation of these pathways can lead to an indirect enhancement of MOSPD3's function. Ionomycin and Thapsigargin, by disrupting calcium homeostasis, can also enhance MOSPD3's activity through the influence of calcium-dependent signaling pathways. Oleic Acid impacts cell membrane dynamics, potentially affecting the interaction of MOSPD3 with other proteins or cellular components, leading to the enhancement of its activity.
The influence of lipid signaling is further exemplified by Sphingosine-1-phosphate (S1P), which activates G-protein-coupled receptors that can result in the modulation of cytoskeletal organization, where MOSPD3 may be functionally active. Inhibition of specific kinases and pathways also plays a critical role in modulating MOSPD3's activity. U0126 and Wortmannin, both inhibitors of key signaling molecules within the MAPK/ERK and PI3K/AKT pathways, respectively, could indirectly increase MOSPD3's activity by altering the balance of intracellular signaling. Additionally, Epigallocatechin gallate (EGCG) broadly inhibits kinases, potentially allowing for MOSPD3 activity enhancement through its effects on cell signaling pathways. Collectively, these activators work through various mechanisms to influence the cellular environment and signaling landscape, thus promoting the functional activity of MOSPD3 without directly impacting its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased production of cyclic AMP (cAMP). Elevated levels of cAMP may enhance MOSPD3's activity by activating protein kinase A (PKA), which could phosphorylate proteins that interact with MOSPD3, influencing its function in cellular processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation is implicated in the modulation of cell motility and cytoskeletal organization, processes in which MOSPD3 may play a role. Enhanced PKC activity could therefore potentially upregulate MOSPD3's activity in these processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium signaling can modulate various cellular processes that may involve MOSPD3, potentially leading to its enhanced activity by modifying the interaction of MOSPD3 with its binding partners. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
As a cAMP analog, 8-Bromo-cAMP mimics the actions of cAMP and activates PKA. This can lead to the enhanced functional activity of MOSPD3 by influencing signaling pathways that regulate cytoskeletal dynamics and cell motility in which MOSPD3 could be involved. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P engages with G-protein-coupled receptors leading to the activation of signaling cascades that can influence cytoskeletal organization. MOSPD3, potentially involved in such cellular processes, may have its activity augmented by S1P-mediated signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that disrupts calcium homeostasis, leading to increased intracellular calcium. This elevation can modulate signaling pathways and cellular processes, potentially enhancing MOSPD3 activity related to calcium-dependent signaling. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid is a fatty acid that can incorporate into cell membranes, affecting membrane fluidity and related signaling. This may influence MOSPD3 activity by modulating the cellular processes associated with membrane dynamics where MOSPD3 is active. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2 within the MAPK/ERK pathway. By inhibiting this pathway, U0126 could shift the signaling balance to enhance signaling mechanisms where MOSPD3 is involved, leading to its potential functional activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that modulates the PI3K/AKT signaling pathway. This inhibition could indirectly enhance MOSPD3's functional activity by altering signaling pathways that intersect with processes where MOSPD3 is active. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor that suppresses the PI3K/AKT pathway. Similar to LY294002, Wortmannin may indirectly lead to the enhanced activity of MOSPD3 by affecting the cellular processes and signaling pathways MOSPD3 is associated with. | ||||||