MondoA Activators
MondoA Activators are a diverse array of chemical compounds that engage with metabolic and stress-responsive pathways within the cell to indirectly enhance the functional activity of MondoA. Metformin and Phenformin, by activating AMPK, pivot cellular metabolism from anabolic to catabolic states, thereby modulating the energy balance and inducing a metabolic milieu that is conducive to MondoA activation. This is echoed by AICAR and Berberine, which also activate AMPK, reinforcing MondoA's rolein the cellular energy stress response. Similarly, compounds like Resveratrol and Nicotinamide mononucleotide (NMN), through SIRT1 activation, modify the cellular redox state and energy homeostasis, indirectly influencing MondoA activity that is pivotal in managing cellular metabolic processes. Oleuropein contributes to this cohort by similar mechanisms, implying a thematic consistency in the activation of MondoA through modulation of energy-sensing pathways.
Furthermore, Palmitate engages MondoA activity by inducing endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) production, which MondoA is responsive to due to its role in managing nutrient overload and stress signals. Troglitazone, although a PPARγ agonist with primary effects on gene expression, can still indirectly impact MondoA function by altering the cellular metabolic landscape. Leptin, typically known as a hormone, can also play a role in adjusting MondoA's activity by altering energy expenditure and glucose homeostasis through its receptor-mediated signaling pathways. Lastly, Salicylate's ability to activate AMPK suggests another avenue through which MondoA's functional activity is indirectly enhanced, emphasizing the importance of these chemical activators in promoting MondoA's role in the intricate network of cellular energy regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin activates AMP-activated protein kinase (AMPK), which in turn can regulate the activity of MondoA by modulating cellular energy levels and metabolic stress. AMPK activation shifts cellular metabolism from anabolic to catabolic processes, which can indirectly enhance the functional activity of MondoA involved in cellular energy balance. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an AMPK agonist. By activating AMPK, it mimics cellular energy depletion, indirectly influencing MondoA activity, as MondoA responds to changes in the energy status of the cell. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a NAD+-dependent deacetylase, which influences cellular metabolism and can indirectly affect MondoA activity by modulating the cellular redox state and energy balance, processes that MondoA is sensitive to. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $359.00 $530.00 $791.00 $6773.00 | 2 | |
Oleuropein has been shown to activate AMPK, potentially enhancing the activity of MondoA through the same mechanism as Metformin and Phenformin, by inducing a cellular energy stress response. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an isoquinoline alkaloid that activates AMPK. Its activation of AMPK can lead to an enhancement of MondoA function, given MondoA’s role in metabolic regulation in response to energy status. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN is a precursor of NAD+ and can activate SIRT1. Through SIRT1 activation, NMN can indirectly enhance the activity of MondoA by influencing cellular energy metabolism and stress responses. | ||||||
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitate, a fatty acid, can induce endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) production, which can indirectly activate MondoA as it responds to cellular stress signals related to nutrient overload. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone is a PPARγ agonist that modulates glucose and lipid metabolism. Although primarily affecting gene expression, its alteration of metabolic pathways can indirectly enhance MondoA activity due to MondoA's role in responding to metabolic changes. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate can activate AMPK, and thereby potentially enhance MondoA activity, by mimicking low energy conditions in the cell which MondoA is known to respond to. | ||||||