mKIAA1853 Inhibitors
Chemical inhibitors of mKIAA1853 target the protein's function by interfering with microtubule dynamics, a critical component of cellular processes such as cell division. Paclitaxel, a chemical known to stabilize microtubules, prevents their disassembly and thus can inhibit mKIAA1853 if the protein relies on the dynamic instability of microtubules for its function. Similarly, drugs like colchicine, vincristine, vinblastine, and podophyllotoxin bind to tubulin, the building block of microtubules, and inhibit its polymerization. This action can lead to the functional inhibition of mKIAA1853 if it is involved in the regulation or maintenance of microtubule assembly. Nocodazole, another inhibitor, disrupts microtubule polymerization, further suggesting that if mKIAA1853's role is intertwined with microtubule-dependent cellular processes, its function can be effectively inhibited.
In addition to these, eribulin and combretastatin A4 specifically target microtubule dynamics by inhibiting the growth phase of microtubules and disrupting tubulin polymerization at the colchicine binding site, respectively. This can impede the function of mKIAA1853 if it is associated with microtubule elongation or spindle function during cell division. Griseofulvin and noscapine alter tubulin conformation and dynamics, which can result in the inhibition of mKIAA1853 activity if it is dependent on correct microtubule function and mitotic spindle formation. Moreover, chemicals like S-Trityl-L-cysteine, which inhibits the mitotic kinesin Eg5, essential for spindle bipolarity, can lead to the inhibition of mKIAA1853 if it has a role in spindle assembly or function. Lastly, dolastatin 10, which induces mitotic arrest by inhibiting tubulin polymerization, can be another inhibitor of mKIAA1853 if the protein is involved with microtubules and cell division processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which could inhibit mKIAA1853 function if the protein is involved in microtubule dynamics, such as spindle formation during cell division. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization, which could inhibit mKIAA1853 by disrupting microtubule functions that the protein may regulate. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule formation by binding to tubulin. Inhibition of microtubules could inhibit mKIAA1853 if the protein's function is related to microtubule assembly or maintenance. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization. If mKIAA1853 has a role in microtubule-dependent cellular processes, nocodazole's action can inhibit the protein's function. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, thus potentially inhibiting mKIAA1853 if it is involved in microtubule dynamics. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization, which could inhibit mKIAA1853 function if the protein is involved in processes depending on microtubule assembly. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by interfering with mitotic spindle formation. If mKIAA1853 plays a role in spindle dynamics, griseofulvin's action would inhibit the protein's function. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine alters tubulin conformation and affects microtubule dynamics, potentially inhibiting mKIAA1853 if the protein is involved in microtubule-based cellular processes. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine specifically inhibits the mitotic kinesin Eg5, which is essential for spindle bipolarity. If mKIAA1853 is involved in spindle assembly or function, inhibition of Eg5 by S-Trityl-L-cysteine could lead to functional inhibition of mKIAA1853. | ||||||
Dolastatin 10 | 110417-88-4 | sc-507413 | 5 mg | $980.00 | ||
Dolastatin 10 inhibits tubulin polymerization and induces mitotic arrest. This action could inhibit mKIAA1853 if the protein's function is associated with microtubules and cell division processes. | ||||||