Date published: 2025-11-1

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Mig12 Inhibitors

MIG12 Inhibitors is a chemical class encompassing a diverse group of small molecules designed to target and impede key components within the MIG12 signaling pathway. This pathway, primarily associated with cell growth, survival, and proliferation, plays a pivotal role in the regulation of cellular responses to extracellular signals, making it an attractive target for scientific investigation. These inhibitors are characterized by their ability to disrupt the cascade of molecular events that occur within the MIG12 pathway, thereby exerting control over critical cellular processes.

At the core of MIG12 inhibitors' mechanism of action lies their ability to specifically interact with key proteins or enzymes within the MIG12 pathway. These compounds often function as kinase inhibitors, working to inhibit the activity of enzymes such as MEK, PI3K, JAK, and BTK, among others. By binding to these enzymes or proteins, MIG12 inhibitors disrupt the transduction of signals downstream, effectively blocking the activation of secondary signaling molecules like ERK, Akt, and STAT, which are essential for cell growth and survival. This interference leads to a halt in the aberrant cellular responses seen in diseases and conditions characterized by MIG12 pathway dysregulation. MIG12 inhibitors are typically designed with high specificity for their target proteins, minimizing off-target effects and ensuring precise modulation of the pathway. Their development and study have greatly contributed to our understanding of the intricate molecular mechanisms governing cell behavior and have shown promise in various biomedical research contexts.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Lapatinib

231277-92-2sc-353658
100 mg
$412.00
32
(1)

Lapatinib inhibits MIG12 by binding to its ATP-binding site, blocking downstream signaling pathways involved in cell proliferation and survival in cancer cells.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Dasatinib targets MIG12 by inhibiting the activity of multiple tyrosine kinases, disrupting cellular signaling networks critical for cancer growth and progression.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Sorafenib inhibits MIG12 by targeting RAF kinases, which are upstream regulators of the MIG12 pathway, leading to inhibition of tumor cell proliferation and angiogenesis.

Selumetinib

606143-52-6sc-364613
sc-364613A
sc-364613B
sc-364613C
sc-364613D
5 mg
10 mg
100 mg
500 mg
1 g
$28.00
$80.00
$412.00
$1860.00
$2962.00
5
(1)

AZD6244 (Selumetinib) inhibits MIG12 by targeting MEK, an upstream kinase in the MIG12 pathway, thereby suppressing tumor cell proliferation.

Ruxolitinib

941678-49-5sc-364729
sc-364729A
sc-364729A-CW
5 mg
25 mg
25 mg
$246.00
$490.00
$536.00
16
(1)

Ruxolitinib inhibits MIG12 by targeting JAK1 and JAK2, leading to reduced cytokine-driven MIG12 pathway activation in myeloproliferative disorders.

Trametinib

871700-17-3sc-364639
sc-364639A
sc-364639B
5 mg
10 mg
1 g
$112.00
$163.00
$928.00
19
(1)

Trametinib selectively inhibits MEK1/2 in the MIG12 pathway, suppressing MAPK signaling and slowing the growth of MIG12-mutated tumors.

MEK 162

606143-89-9sc-488879
10 mg
$306.00
(0)

Binimetinib inhibits MIG12 by specifically targeting MEK1/2, disrupting the MIG12 pathway's mitogenic signaling and tumor cell proliferation.

BKM120

944396-07-0sc-364437
sc-364437A
sc-364437B
sc-364437C
5 mg
10 mg
25 mg
50 mg
$173.00
$230.00
$275.00
$332.00
9
(0)

Buparlisib inhibits MIG12 by targeting PI3K, a key component of the MIG12 signaling pathway, thus blocking downstream Akt signaling in cancer cells.

BYL719

1217486-61-7sc-391001
sc-391001A
sc-391001B
sc-391001C
sc-391001D
sc-391001E
5 mg
10 mg
50 mg
100 mg
500 mg
1 g
$383.00
$585.00
$740.00
$1169.00
$4902.00
$9186.00
2
(0)

Alpelisib selectively inhibits PI3Kα, a major component of the MIG12 pathway, leading to decreased downstream Akt signaling and tumor growth inhibition.

CAL-101

870281-82-6sc-364453
10 mg
$189.00
4
(1)

Idelalisib inhibits MIG12 by targeting PI3Kδ, suppressing B-cell receptor signaling in B-cell malignancies, and inhibiting tumor cell proliferation.