MIER2 Inhibitors
MIER2 inhibitors encompass a variety of chemical compounds that interfere with specific signaling pathways or cellular processes to decrease the functional activity of MIER2. For instance, protein kinase inhibitors like staurosporine can inhibit a wide range of kinases, which could prevent the phosphorylation events necessary for MIER2's activity. Similarly, PI3K inhibitors such as LY294002 and Wortmannin could prevent the activation of the PI3K/Akt pathway, leading to reduced MIER2 activity if it is dependent on this pathway for its activity or stability. MEK inhibitors like U0126 and PD98059 could prevent the activation of the ERK/MAPK pathway, which might be necessary for the phosphorylation and subsequent activation or stabilization of MIER2.
Furthermore, mTOR inhibition by compounds like rapamycin could lead to a decrease in MIER2 activity if MIER2 is regulated by mTOR-dependent pathways. Inhibition of kinases, such as Src family kinases by PP2 and AZD0530, or FGFR by PD173074, could decrease MIER2 activity if it relies on signaling mediated by these kinases.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that hinders the activity of protein kinases by mimicking ATP at their binding sites. Interfering with these kinases could reduce the phosphorylation-dependent activation or stabilization of MIER2, thus inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI3K, a key component in the PI3K/Akt signaling pathway. Disruption of this pathway can lead to altered cellular responses and potentially inhibit MIER2 if its activity is dependent on signals propagated through PI3K. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase, which is involved in response to stress stimuli and cytokines. If MIER2 activity is modulated by p38 MAPK signaling, inhibition by SB203580 could lead to decreased MIER2 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which is involved in controlling gene expression and cellular apoptosis. If JNK signaling influences MIER2 activity, inhibition by SP600125 could decrease MIER2 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is upstream of ERK in the MAPK pathway. Inhibition of this pathway by PD98059 could lead to decreased phosphorylation and activation of MIER2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in cell growth and protein synthesis. Inhibition of mTOR by Rapamycin could lead to a decrease in MIER2 activity if MIER2 is downstream of mTOR signaling. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that could disrupt the PI3K/Akt pathway. If MIER2 requires PI3K/Akt-mediated signaling for its activity, inhibition by Wortmannin could lead to decreased MIER2 activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a Src family kinase inhibitor that could disrupt Src kinase-mediated signaling pathways. If MIER2 is regulated by Src kinase signaling, inhibition by PP2 could decrease MIER2 activity. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 inhibits FGFR1 tyrosine kinase activity. If MIER2 is regulated by FGFR-mediated signaling, inhibition by PD173074 could lead to decreased MIER2 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that can affect actin cytoskeleton arrangement. If the function of MIER2 is connected to cytoskeletal dynamics influenced by ROCK, inhibition by Y-27632 could decrease MIER2 activity. | ||||||