MIER2 Activators
Chemical activators of MIER2 can influence its regulatory functions through various biochemical pathways, each targeting different aspects of cellular control and gene expression. Forskolin acts by elevating cAMP levels which, in turn, activates protein kinase A (PKA). PKA phosphorylates a range of target proteins, including those involved in transcription machinery with which MIER2 interacts. This can enhance MIER2's role in gene regulation by facilitating its interaction with transcriptional complexes. Similarly, Trichostatin A, by inhibiting histone deacetylases, leads to a more relaxed chromatin structure, which may allow MIER2 better access to DNA for regulating gene expression. The effect of 5-Azacytidine contributes to this process from a different angle by inhibiting DNA methylation, which also results in increased chromatin accessibility for MIER2.
Anacardic acid, by inhibiting histone acetyltransferase, creates an environment where the chromatin landscape is altered, potentially making it more amenable to MIER2's regulatory activities. Piceatannol and SRT1720 work through modulating kinase activity and sirtuin activity, respectively, altering the phosphorylation and acetylation status of proteins within the cell, which can, in turn, influence how MIER2 modulates gene expression. ZM-447439, another kinase inhibitor, specifically targets Aurora kinases, which can lead to changes in the phosphorylation of proteins involved in chromatin organization, a process that is critical for MIER2's role in gene regulation. RG108, like 5-Azacytidine, prevents DNA methylation, supporting MIER2's ability to regulate gene expression by enhancing chromatin accessibility. Lastly, SP600125 and SB431542 inhibit JNK and TGF-beta receptor signaling, respectively, leading to alterations in gene expression patterns that are conducive to MIER2's regulatory functions. PF-4708671's specific inhibition of p70 S6 Kinase 1 influences protein synthesis and cell growth signaling pathways, which can indirectly support MIER2's transcriptional regulatory functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases cAMP levels, leading to the activation of protein kinase A (PKA). PKA directly phosphorylates target proteins, including the transcriptional machinery that MIER2 is known to interact with, thereby enhancing MIER2's role in gene regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea that influences multiple signaling pathways, including those regulating histone acetylation and DNA methylation. Since MIER2 interacts with chromatin remodeling complexes, EGCG can promote the structural changes necessary for MIER2 to access and regulate its target gene sequences. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that alters chromatin structure, enhancing access for transcription factors. MIER2's function is related to gene regulation; therefore, the increased acetylation of histones could facilitate MIER2's binding to its target DNA sequences, promoting its activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that leads to hypomethylation of DNA. As MIER2 is involved in gene regulation, the reduction of DNA methylation can enhance the gene regulatory functions of MIER2 by increasing the accessibility of transcription factor binding sites. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid inhibits histone acetyltransferase, which could paradoxically activate MIER2 by altering the balance of histone acetylation and deacetylation, thereby making specific gene regions more accessible for regulation by MIER2. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $50.00 $70.00 $195.00 | 11 | |
Piceatannol inhibits Syk kinase, which may lead to altered phosphorylation states of proteins within signaling pathways that MIER2 is part of. This alteration can enhance the transcriptional regulatory functions of MIER2 in response to changes in cellular signaling. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $193.00 $357.00 | 13 | |
SRT1720 is an activator of SIRT1, a deacetylase that is involved in the regulation of gene expression. Activation of SIRT1 can lead to changes in chromatin structure, which may facilitate MIER2's interaction with its target genes, promoting its regulatory function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. Inhibition of Aurora kinases can result in altered phosphorylation states of proteins involved in chromatin organization and gene regulation, potentially enhancing the activity of MIER2 in gene regulatory processes. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor. By preventing DNA methylation, RG108 can increase the accessibility of chromatin for transcription factors, including MIER2, thus potentially enhancing MIER2's role in gene regulation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which modulates transcription factors and gene expression. Inhibition of JNK can result in changes in transcriptional regulation, potentially enabling MIER2 to more effectively activate its target genes. | ||||||