MICAL1 Activators
MICAL1 Activators comprise a diverse array of chemical compounds that indirectly enhance the functional activity of MICAL1, primarily through their influence on cellular redox states and substrate availability. Selenium plays a pivotal role by contributing to the structural integrity of MICAL1 and influencing the redox regulation within cells, a factor crucial for MICAL1's enzymatic activity. Similarly, NADPH, as a provider of reducing equivalents, is essential for the reduction of MICAL1's FAD cofactor, enabling its actin-modifying function. The presence of polymerized F-actin, promoted by water, provides MICAL1 with substrates to act upon, thus enhancing its activity. Compounds like Hydrogen Peroxide, L-Phenylalanine, and L-Tyrosine, though not directly interacting with MICAL1, modulate the redox environment in which MICAL1 operates. Pyruvate and Alpha-ketoglutarate, key metabolites in cellular respiration, also influence MICAL1's activity by altering the NAD+/NADH ratio, which is integral to maintaining the redox balance that MICAL1 requires.
Further contributing to the functional enhancement of MICAL1 are compounds like Ascorbic Acid and Reduced Glutathione, which maintain a reductive environment crucial for MICAL1's redox-sensitive mechanisms. Riboflavin, through its role in FAD synthesis, indirectly supports MICAL1's enzymatic processes by ensuring the availability of this essential cofactor. Copper (II) sulfate, by participating in cellular redox reactions, can also impact the activity of MICAL1, albeit indirectly. Collectively, these activators do not directly bind or interact with MICAL1; instead, they create an intracellular milieu conducive to its optimal functioning, predominantly by modulating the redox state and providing essential substrates and cofactors. This intricate network of biochemical interactions and dependencies highlights the nuanced and multi-faceted nature of MICAL1's regulation and activity within the cellular environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium, an essential trace element, is known to enhance the activity of MICAL1 by contributing to its proper folding and structural integrity. Selenium-dependent enzymes are crucial for the redox regulation in cells, and MICAL1, being a redox enzyme itself, relies on the cellular redox state, which selenium can influence. | ||||||
NADPH tetrasodium salt | 2646-71-1 | sc-202725 sc-202725A sc-202725B sc-202725C | 25 mg 50 mg 250 mg 1 g | $46.00 $82.00 $280.00 $754.00 | 11 | |
NADPH provides the necessary reducing equivalents for MICAL1's enzymatic activity. MICAL1, a flavoenzyme, utilizes NADPH to reduce its flavin adenine dinucleotide (FAD) cofactor, which is essential for its actin-modifying activity. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide can indirectly enhance the activity of MICAL1. As a reactive oxygen species, it can alter the redox environment of the cell, which in turn can modulate the activity of redox-sensitive proteins like MICAL1. | ||||||
L-Phenylalanine | 63-91-2 | sc-394058 sc-394058A sc-394058B | 100 g 500 g 1 kg | $112.00 $457.00 $679.00 | 1 | |
L-Phenylalanine can indirectly influence MICAL1 activity. As a substrate for various hydroxylases, it can affect the cellular redox state. Since MICAL1 is sensitive to redox changes, alterations in the redox environment can indirectly enhance its activity. | ||||||
L-Tyrosine | 60-18-4 | sc-473512 sc-473512A sc-473512B sc-473512C | 100 g 250 g 1 kg 5 kg | $51.00 $209.00 $1637.00 $8165.00 | 1 | |
L-Tyrosine, similar to L-Phenylalanine, can affect MICAL1's activity indirectly. As a substrate for tyrosine hydroxylases, it participates in cellular redox processes, influencing the environment MICAL1 operates in. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
Pyruvate, a key metabolite in cellular respiration, can influence the redox state of the cell. By modulating the NAD+/NADH ratio, it can indirectly affect the redox-sensitive MICAL1. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Ascorbic acid, a well-known antioxidant, can modulate the cellular redox state. By maintaining a reduced environment, it can facilitate the proper function of redox-sensitive enzymes like MICAL1. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $32.00 $42.00 $62.00 $108.00 $184.00 $724.00 $2050.00 | 2 | |
Alpha-ketoglutarate, a critical intermediate in the TCA cycle, influences cellular redox status. By affecting the balance of NADH and FADH2, it can indirectly affect the activity of MICAL1. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $76.00 $2050.00 | 8 | |
Reduced glutathione maintains a reductive environment in cells, which is essential for the activity of redox-sensitive proteins like MICAL1. It can enhance MICAL1's function by maintaining its required redox state. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $40.00 $110.00 $515.00 | 3 | |
Riboflavin, or vitamin B2, is crucial for the synthesis of FAD, a cofactor for MICAL1. By ensuring the availability of FAD, riboflavin indirectly enhances the functional activity of MICAL1. | ||||||