MGMT Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diethylamine NONOate | 372965-00-9 | sc-202575 sc-202575A sc-202575B sc-202575C | 10 mg 50 mg 100 mg 500 mg | $37.00 $111.00 $199.00 $882.00 | 1 | |
Diethylamine NONOate is a unique compound known for its ability to release nitric oxide upon hydrolysis, facilitating various signaling pathways. Its structure allows for rapid diffusion across membranes, enhancing its reactivity with biological targets. The compound exhibits distinct electron-donating properties, which can influence redox reactions. Additionally, its interactions with metal ions can modulate catalytic processes, showcasing its versatility in chemical reactivity and molecular dynamics. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $89.00 $250.00 | 32 | |
Temozolomide is an alkylating agent that methylates DNA at the O6 position of guanine. MGMT repairs this DNA damage by transferring the methyl group from O6-methylguanine to its active site, thus inactivating MGMT. Temozolomide inhibits MGMT, allowing O6-methylguanine to persist and trigger DNA mismatch repair, eventually leading to cell death. | ||||||
O6-Benzylguanine | 19916-73-5 | sc-202747 sc-202747A | 10 mg 50 mg | $50.00 $77.00 | 7 | |
6-Benzylthioinosine is an MGMT inhibitor that has been explored for its ability to sensitize cancer cells to alkylating agents. It interferes with the repair of O6-methylguanine lesions by MGMT, leading to DNA damage accumulation and potential cell death. | ||||||
Lomeguatrib | 192441-08-0 | sc-362764 sc-362764A | 10 mg 50 mg | $205.00 $865.00 | ||
Lomeguatrib is a suicide inhibitor of MGMT. It irreversibly binds to the active site of MGMT, forming a covalent complex that prevents MGMT from repairing O6-methylguanine lesions in DNA. This enhances the efficacy of alkylating agents used in cancer chemotherapy. | ||||||
NU2058 | 161058-83-9 | sc-202744 sc-202744A | 5 mg 25 mg | $66.00 $321.00 | 2 | |
NU2058 is another pseudosubstrate for MGMT that functions similarly to O6-Benzylguanine. It irreversibly inhibits MGMT by forming a covalent complex, preventing the repair of O6-methylguanine lesions in DNA. | ||||||
Semustine | 13909-09-6 | sc-391062 | 100 mg | $114.00 | 1 | |
Semustine is an alkylating agent that induces the formation of O6-methylguanine lesions in DNA. MGMT repairs these lesions by transferring the methyl group to its active site. Inhibition of MGMT by Methyl-CCNU can enhance the cytotoxic effects of alkylating chemotherapy. | ||||||
6-Ethyl Guanine | 51866-19-4 | sc-496096 | 1 g | $393.00 | ||
O6-Ethylguanine is structurally similar to O6-methylguanine and acts as a substrate for MGMT. It binds to MGMT's active site and inactivates the enzyme by transferring the alkyl group from O6-ethylguanine. This prevents repair of O6-ethylguanine lesions. | ||||||