Molecular structure of Diethylamine NONOate, CAS Number: 372965-00-9
Diethylamine NONOate (CAS 372965-00-9)
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Alternate Names:
Diethylamine NONOate
Application:
Diethylamine NONOate is a quick-releasing NO donor and MGMT inhibitor
CAS Number:
372965-00-9
Purity:
>98%
Molecular Weight:
206.29
Molecular Formula:
C4H11N3O2•C4H11N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diethylamine NONOate also known as DEA NONOate is a small molecule NO donor with a reported NO release half-life of 16 min (22-25degC). Diethylamine NONOate is useful for screening assays investigating the effects of differential rates of NO release in comparison with other NO releasing compounds. NO release from Diethylamine NONOate is believed to protect V79 lung fibroblast cells from the oxidative damage conferred by a hypoxanthine/xanthine oxidase/H2O2 model of ischemic reperfusion. The activity of O6-methylguanine-DNA-methyltransferase (MGMT) is inhibited by NO release from Diethylamine NONOate with a correlated formation of an S-nitrosothiol adduct on the enzyme.
Diethylamine NONOate (CAS 372965-00-9) References
- Involvement of cyclic GMP and potassium channels in relaxation evoked by the nitric oxide donor, diethylamine NONOate, in the rat small isolated mesenteric artery. | Sampson, LJ., et al. 2001. Naunyn Schmiedebergs Arch Pharmacol. 364: 220-5. PMID: 11521164
- Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter. | Granillo, OM., et al. 2008. Am J Physiol Lung Cell Mol Physiol. 295: L38-43. PMID: 18441097
- Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. | Maragos, CM., et al. 1991. J Med Chem. 34: 3242-7. PMID: 1956043
- Cyclic guanosine monophosphate dependent pathway contributes to human mast cell inhibitory actions of the nitric oxide donor, diethylamine NONOate. | Yip, KH., et al. 2010. Eur J Pharmacol. 632: 86-92. PMID: 20096283
- The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate. | Wang, C., et al. 2016. Front Pharmacol. 7: 91. PMID: 27065874
- Fluorescent Calixarene Scaffolds for NO Detection in Protic Media. | Ahuja, BB. and Vigalok, A. 2019. Angew Chem Int Ed Engl. 58: 2774-2778. PMID: 30653807
- Antimicrobial properties of diethylamine NONOate, a nitric oxide donor, against Escherichia coli: a pilot study. | Sysel, AM., et al. 2021. J Antibiot (Tokyo). 74: 260-265. PMID: 33361779
- Products of S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase: Relation between S-nitrosylation and oxidation. | Schmalhausen, EV., et al. 2022. Biochim Biophys Acta Gen Subj. 1866: 130032. PMID: 34627945
- Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators. | Morley, D. and Keefer, LK. 1993. J Cardiovasc Pharmacol. 22 Suppl 7: S3-9. PMID: 7504766
- Inhibition by nitric oxide of the repair protein, O6-methylguanine-DNA-methyltransferase. | Laval, F. and Wink, DA. 1994. Carcinogenesis. 15: 443-7. PMID: 8118926
- Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species. | Wink, DA., et al. 1993. Proc Natl Acad Sci U S A. 90: 9813-7. PMID: 8234317
- Nitric oxide/nucleophile complexes inhibit the in vitro proliferation of A375 melanoma cells via nitric oxide release. | Maragos, CM., et al. 1993. Cancer Res. 53: 564-8. PMID: 8425188
- 'NONOates' (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. | Keefer, LK., et al. 1996. Methods Enzymol. 268: 281-93. PMID: 8782594
Inhibitor of:
MGMT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diethylamine NONOate, 10 mg | sc-202575 | 10 mg | $38.00 | |||
Diethylamine NONOate, 50 mg | sc-202575A | 50 mg | $113.00 | |||
Diethylamine NONOate, 100 mg | sc-202575B | 100 mg | $203.00 | |||
Diethylamine NONOate, 500 mg | sc-202575C | 500 mg | $900.00 |