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O6-Benzylguanine is an effective substrate and efficient inactivator of DNA alkyltransferase. O6-Benzylguanine is an inhibitor of MGMT.
1. Goodtzova, K., et al., 1994. Activation of human O6-alkylguanine-DNA alkyltransferase by DNA. Biochemistry. 33(28): 8385-90. PMID: 8031773
2. Elder, R H., et al., 1994. Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine. The Biochemical journal. 298 ( Pt 1)(): 231-5. PMID: 8129725
3. Dolan, M E., et al., 1997. O6-benzylguanine and its role in chemotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 3(6): 837-47. PMID: 9815757
4. Kreklau, E L., et al., 1999. Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. 291(3): 1269-75. PMID: 10565851
See how others have used O6-Benzylguanine. Click on the entry to view the PubMed entry .
PMID: # 29666243 Ezerskyte, M.|Paredes, JA.|Malvezzi, S.|Burns, JA.|Margison, GP.|Olsson, M.|Scicchitano, DA.|Dreij, K.| et al. 2018. Proc. Natl. Acad. Sci. U.S.A. 115: 4731-4736.
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