6-Ethyl Guanine (CAS 51866-19-4)
Alternate Names:
6-Ethylguanine; 6-Ethoxy-9H-purin-2-amine; 2-Amino-6-ethoxypurine; 2-Amino-6-ethoxypurine; 6-Ethoxy-1H-purin-2-amine; 6-O-Ethylguanine; NSC 37368; O6-Ethylguanine
CAS Number:
51866-19-4
Molecular Weight:
179.18
Molecular Formula:
C7H9N5O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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6-Ethyl Guanine (6-EG) holds significant importance and versatility within the realm of biochemistry. Serving as a modified version of guanine, it plays a pivotal role in altering the structure of DNA and RNA, enabling the synthesis of novel genetic material. Moreover, it facilitates the modification of existing genetic material, thereby providing a means to study the impacts of genetic modifications on organisms. As a "methylating agent", 6-Ethyl Guanine possesses the ability to attach a methyl group to specific molecules. This capability empowers it to modify the structure of DNA and RNA, ultimately resulting in the synthesis of fresh genetic material. Furthermore, it allows for the modification of pre-existing genetic material, enabling comprehensive exploration into the effects of genetic alterations on organisms.
6-Ethyl Guanine (CAS 51866-19-4) References
- DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance. | Rajewsky, MF., et al. 2000. Mutat Res. 462: 101-5. PMID: 10767621
- Role of DNA repair in carcinogen-induced ras mutation. | Engelbergs, J., et al. 2000. Mutat Res. 450: 139-53. PMID: 10838139
- Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea. | Thomale, J., et al. 1990. Proc Natl Acad Sci U S A. 87: 9883-7. PMID: 2263639
- Modulation of diethylnitrosamine-induced hepatocarcinogenesis and O6-ethylguanine formation in rainbow trout by indole-3-carbinol, beta-naphthoflavone, and Aroclor 1254. | Fong, AT., et al. 1988. Toxicol Appl Pharmacol. 96: 93-100. PMID: 3142102
- Formation and persistence of ethylguanines in liver DNA of rainbow trout (Salmo gairdneri) treated with diethylnitrosamine by water exposure. | Fong, AT., et al. 1988. Food Chem Toxicol. 26: 699-704. PMID: 3198036
- Repair of synthetic oligonucleotides containing O6-methylguanine, O6-ethylguanine and O4-methylthymine, by O6-alkylguanine-DNA alkyltransferase. | Graves, RJ., et al. 1987. IARC Sci Publ. 41-3. PMID: 3316001
- Action of phenobarbital given to rats together with diethylnitrosamine on the O6-ethylguanine content of liver DNA. | Brumioul, D., et al. 1988. Eur J Cancer Clin Oncol. 24: 1117-21. PMID: 3416896
- Quantitative comparison of genetic effects of ethylating agents on the basis of DNA adduct formation. Use of O6-ethylguanine as molecular dosimeter for extrapolation from cells in culture to the mouse. | van Zeeland, AA., et al. 1985. Environ Health Perspect. 62: 163-9. PMID: 3910416
- Enzymatic elimination of O6-ethylguanine and stability of O4-ethylthymine in the DNA of malignant neural cell lines exposed to N-ethyl-N-nitrosourea in culture. | Huh, N. and Rajewsky, MF. 1986. Carcinogenesis. 7: 435-9. PMID: 3948328
- Persistence of O6-ethylguanine in rat-brain DNA: correlation with nervous system-specific carcinogenesis by ethylnitrosourea. | Goth, R. and Rajewsky, MF. 1974. Proc Natl Acad Sci U S A. 71: 639-43. PMID: 4522778
- Mutagenesis and O6-ethylguanine levels in DNA from N-nitroso-N-ethylurea-treated Salmonella typhimurium: evidence for a high mutational efficiency of O6-ethylguanine. | Guttenplan, JB. 1984. Carcinogenesis. 5: 155-9. PMID: 6365347
- Repair of O6-ethylguanine DNA lesions in isolated cell nuclei. Presence of the activity in the chromatin proteins. | Renard, A. and Verly, WG. 1983. Eur J Biochem. 136: 453-60. PMID: 6641726
- Enzymatic synthesis of double-stranded DNA containing radioactively labeled O(6)-ethylguanine as the only modified base. | Müller, R., et al. 1981. Carcinogenesis. 2: 321-7. PMID: 7273313
- Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea. | Engelbergs, J., et al. 1998. Proc Natl Acad Sci U S A. 95: 1635-40. PMID: 9465068
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Ethyl Guanine, 1 g | sc-496096 | 1 g | $393.00 |