METTL7B Activators
METTL7B Activators are chemical compounds that specifically enhance the functional activity of METTL7B, a protein involved in the cAMP-PKA pathway. These activators mainly act by increasing the levels of cAMP, which is a crucial second messenger involved in multiple biological processes. For example, Epinephrine, Isoproterenol, PGE2, PACAP, GLP-1, VIP, Dopamine, Histamine, and Serotonin are all able to increase cAMP levels by activating specific receptors that are involved in the cAMP-PKA pathway that METTL7B is a part of. The increased cAMP levels can enhance the activity of PKA, leading to an increase in the functional activity of METTL7B.
In addition, some METTL7B Activators function by inhibiting the breakdown of cAMP, leading to increased levels of this second messenger in the cell. Forinstance, Rolipram and IBMX are known to inhibit phosphodiesterase, an enzyme responsible for the breakdown of cAMP, thereby leading to elevated cAMP levels. These increased levels, in turn, enhance the activity of PKA, a key component of the cAMP-PKA pathway. This effect directly leads to the heightened functional activity of METTL7B, as it is an integral part of this pathway. The entire collection of METTL7B Activators, therefore, ensures a range of mechanisms to increase cAMP levels and, consequently, enhance the functional activity of METTL7B. These actions can be either through direct receptor activation or through inhibition of cAMP degradation, both ultimately leading to the enhancement of METTL7B activity via the cAMP-PKA pathway.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates the β-adrenoceptor, which is part of the cAMP-PKA pathway. METTL7B is involved in this pathway, and its activity can be enhanced by increased cAMP levels leading to greater PKA activation, which promotes the functional activity of METTL7B. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin stimulates adenylate cyclase, leading to increased cAMP levels. The elevated cAMP levels enhance PKA activity, which is involved in the cAMP-PKA pathway that METTL7B is a part of, leading to an increase in the functional activity of METTL7B. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a β-adrenoceptor agonist that increases cAMP levels. The increase in cAMP enhances PKA activity, thereby promoting the functional activity of METTL7B, which is involved in the cAMP-PKA pathway. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, preventing the breakdown of cAMP. The resulting increase in cAMP levels enhance PKA activity, which is involved in the cAMP-PKA pathway that METTL7B is a part of, leading to an increase in the functional activity of METTL7B. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterase, preventing the breakdown of cAMP. Increased cAMP levels enhance PKA activity, which is involved in the cAMP-PKA pathway that METTL7B is a part of, leading to an increase in the functional activity of METTL7B. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 activates the EP2 receptor, which is involved in the cAMP-PKA pathway. This can enhance PKA activity, leading to an increase in the functional activity of METTL7B. | ||||||
PACAP(6-38) | 137061-48-4 | sc-391136 sc-391136A | 500 µg 1 mg | $529.00 $914.00 | ||
PACAP activates the PAC1 receptor, which can increase cAMP levels. The increased cAMP levels enhance PKA activity, which is involved in the cAMP-PKA pathway that METTL7B is a part of, leading to increased functional activity of METTL7B. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can activate the D1-like receptor, which is involved in the cAMP-PKA pathway. This can enhance PKA activity, leading to an increase in the functional activity of METTL7B. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can activate the H2 receptor, which is involved in the cAMP-PKA pathway. This can enhance PKA activity, leading to an increase in the functional activity of METTL7B. | ||||||
Serotonin hydrochloride | 153-98-0 | sc-201146 sc-201146A | 100 mg 1 g | $116.00 $183.00 | 15 | |
Serotonin can activate the 5-HT4, 5-HT6, and 5-HT7 receptors, which are involved in the cAMP-PKA pathway. This can enhance PKA activity, leading to an increase in the functional activity of METTL7B. | ||||||