METTL5 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $120.00 | 5 | |
Chaetocin is a known inhibitor of histone methyltransferases and can inhibit METTL5 by occupying the binding site for the enzyme's substrates, preventing methylation. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
BIX-01294 is a diazepin-quinazolin-amine derivative that inhibits G9a and GLP histone methyltransferases and can inhibit METTL5 by interfering with the substrate binding site, hindering its methyltransferase activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a non-nucleoside DNA methyltransferase inhibitor that can also inhibit protein methyltransferases such as METTL5 by binding to the active site and blocking the enzyme's access to its substrates. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a cytidine analog that incorporates into DNA and can indirectly inhibit DNA methyltransferases. While it primarily targets DNA, it can also inhibit protein methyltransferases such as METTL5 by sequestering SAM and preventing its use as a methyl donor. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Hydralazine is known to demethylate DNA indirectly by inhibiting DNA methyltransferases. It can exert a similar inhibitory effect on protein methyltransferases like METTL5 by depleting the pool of SAM, the methyl donor used by these enzymes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid polyphenol, has been shown to inhibit a range of protein kinases. Its broad action on kinase inhibition can disrupt phosphorylation-dependent regulation of methyltransferases, therefore, it can indirectly inhibit METTL5's activity by preventing essential phosphorylation that may be necessary for its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a catechin found in green tea with inhibitory effects on various enzymes, including DNA methyltransferases. EGCG can inhibit METTL5 by altering the enzyme's conformation or by competing with SAM, thus preventing the methylation of METTL5's target substrates. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Anacardic acid is a natural compound that inhibits histone acetyltransferases and has been suggested to inhibit other methyltransferases by binding to the active site. It can interfere with METTL5's ability to access its substrates, thereby inhibiting its methylation function. | ||||||