METTL5 Activators
Chemical activators of METTL5 include a variety of compounds that contribute to the protein's methylation activity. S-Adenosylmethionine (SAMe) is a primary methyl donor in numerous methylation reactions, and its availability is a direct contributor to the activation of METTL5. The synthesis of SAMe is dependent on the methionine cycle, where Methionine serves as a precursor. In this cycle, Betaine donates a methyl group to homocysteine to regenerate Methionine, which is then adenosylated to form S-Adenosylmethionine. This cycle is complemented by Folic Acid and Vitamin B12 (Cobalamin), which are necessary for the conversion of homocysteine back to Methionine, thereby ensuring a consistent supply of SAMe for use by METTL5. Vitamin B12 in the form of Cobalamin is specifically necessary for the methionine synthase reaction, which is integral to this process.
Additionally, Choline can be metabolized to Betaine, which, as mentioned, participates in the methionine cycle. Magnesium and Zinc both serve as essential cofactors for enzymes in this cycle. Magnesium is necessary for the function of methionine adenosyltransferase, the enzyme responsible for the synthesis of SAMe, while Zinc may also serve as a structural or catalytic cofactor for this enzyme, thus enhancing the activation of METTL5. Pyridoxal phosphate, the active form of Vitamin B6, acts as a coenzyme for transsulfuration enzymes, which helps to maintain the necessary levels of Methionine for SAMe production. Nicotinamide adenine dinucleotide (NAD+) is a cofactor in the conversion of homocysteine to Methionine, indirectly supporting the methylation capacity of METTL5. Lastly, Serine is involved in the folate cycle, which ensures an adequate supply of one-carbon units for Methionine synthesis, thereby sustaining the activation of METTL5 through the generation of SAMe. All these compounds work in a concerted manner to ensure the active methylation function of METTL5 is maintained by providing the necessary substrates and co-factors required for its enzymatic activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
S-Adenosylmethionine serves as a methyl donor in methylation reactions, catalyzed by methyltransferases such as METTL5, thus directly contributing to its methyltransferase activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic Acid is crucial for the generation of S-Adenosylmethionine through one-carbon metabolism, and by increasing the pool of S-Adenosylmethionine, Folic Acid can enhance the methylation activity of METTL5. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Vitamin B12 is involved in the synthesis of S-Adenosylmethionine and, by extension, can facilitate the methylation reactions performed by METTL5. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine acts as a methyl donor in the methionine cycle, which is tightly linked to the generation of S-Adenosylmethionine, thereby supporting the activation of METTL5's enzymatic function. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine is a precursor to S-Adenosylmethionine and can boost its levels, directly contributing to the methyltransferase function of METTL5. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline can be oxidized to betaine, which then participates in the methionine cycle to produce S-Adenosylmethionine, indirectly supporting the activation of METTL5. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor for reactions that generate methionine from homocysteine; since methionine is a precursor for S-Adenosylmethionine, NAD+ indirectly supports the activation of METTL5. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal phosphate serves as a coenzyme for transsulfuration enzymes, which convert homocysteine to cysteine while indirectly maintaining the methionine pool for S-Adenosylmethionine synthesis, thus activating METTL5. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc may act as a structural or catalytic cofactor for methionine adenosyltransferase, the enzyme that synthesizes S-Adenosylmethionine, hence potentiating the methyltransferase activity of METTL5. | ||||||