MEL-28 Activators
MEL-28, also known as Exportin-6 or EXP6, is a protein that is primarily involved in nuclear envelope formation and the regulation of nuclear transport. Named after its initial identification in the nematode Caenorhabditis elegans, MEL-28 plays a crucial role in the proper functioning of the cell.One of the important functions of MEL-28 is during cell division, particularly in the reformation of the nuclear envelope after mitosis. MEL-28 helps to guide the assembly of nuclear pore complexes, structures that control the passage of molecules between the nucleus and the cytoplasm.
MEL-28 also functions as a nuclear export receptor for the protein RanGTP, which is involved in the transport of RNA and proteins through the nuclear pore complex. In this role, MEL-28 is vital for maintaining the proper balance of proteins between the nucleus and the cytoplasm.In addition to these functions, MEL-28 is implicated in the regulation of gene expression, acting through mechanisms that are not yet fully understood. Disruptions in the function of MEL-28 can lead to problems with cell division and gene expression, which can have wide-ranging impacts on cellular health and function.The role of MEL-28 in disease is not fully understood, but given its importance in fundamental cellular processes, it is a promising area of research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JNK Inhibitor XVI | 1410880-22-6 | sc-364745 | 10 mg | $350.00 | 5 | |
Importazole, an inhibitor of the nuclear import receptor importin-β, might indirectly influence MEL-28 activity by altering nuclear transport. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin, known for its activity against parasitic infections, has been shown to disrupt nuclear transport, potentially affecting MEL-28. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole, a microtubule polymerization inhibitor, can create stress conditions that indirectly impact nuclear envelope dynamics involving MEL-28. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A, a fungal metabolite that disrupts Golgi apparatus dynamics, might have an indirect effect on nuclear envelope processes involving MEL-28. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132, a proteasome inhibitor, can affect various cellular processes, potentially having an indirect impact on MEL-28 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, can affect multiple cellular signaling pathways, potentially influencing MEL-28 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride, known to inhibit GSK-3β and modulate the Wnt pathway, could have an indirect effect on nuclear processes involving MEL-28. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, through its various cellular effects, might indirectly impact nuclear envelope dynamics and consequently MEL-28's function. | ||||||