Date published: 2026-3-24

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Med7 Inhibitors

MED7 inhibitors would conceptually belong to a class of compounds that specifically inhibit the function of the MED7 subunit of the mediator complex, but such a class is not well-defined due to the rarity of such specific inhibitors. Instead, compounds that affect the mediator complex tend to have broader targets within the transcription machinery. The inhibition of mediator complex subunits like MED7 involves the disruption of protein-protein interactions necessary for the assembly and function of the complex, which is essential for the correct initiation and regulation of gene transcription. These inhibitors could work by preventing the mediator complex from effectively communicating regulatory signals from transcription factors to the RNA polymerase II enzyme, thereby reducing gene transcription. Since the mediator complex is involved in nearly all aspects of mRNA synthesis, compounds that inhibit MED7 or other subunits can have wide-ranging effects on cell function and gene expression. These effects might be due to the prevention of the complex's assembly, the inhibition of its interaction with other transcriptional regulators, or the blockade of its ability to respond to environmental or cellular signals.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

A diterpene triepoxide that inhibits the general transcription machinery, thereby indirectly reducing MED7 activity as part of the mediator complex.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

A compound that intercalates into DNA and prevents the transcriptional machinery from accessing the DNA, thus indirectly inhibiting MED7 function.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$43.00
$189.00
$316.00
$663.00
6
(1)

A compound that inhibits positive transcription elongation factor b (P-TEFb), indirectly affecting transcription complexes involving MED7.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

A cyclic peptide toxin from the Amanita mushroom that inhibits RNA polymerase II, which would indirectly affect MED7's role in transcription.

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$259.00
41
(3)

A broad CDK inhibitor that can interfere with the phosphorylation of RNA polymerase II, subsequently influencing MED7 activity.

(±)-JQ1

1268524-69-1sc-472932
sc-472932A
5 mg
25 mg
$231.00
$863.00
1
(0)

A BET bromodomain inhibitor that affects the transcription of certain genes, potentially altering the function of mediator complex subunits like MED7.

Mithramycin A

18378-89-7sc-200909
1 mg
$55.00
6
(1)

A compound that binds to DNA and disrupts transcription, indirectly affecting MED7's role in the mediator complex.

Rocaglamide

84573-16-0sc-203241
sc-203241A
sc-203241B
sc-203241C
sc-203241D
100 µg
1 mg
5 mg
10 mg
25 mg
$275.00
$474.00
$1639.00
$2497.00
$5344.00
4
(1)

A natural product that inhibits translation and could indirectly suppress the activity of the mediator complex, including MED7.

Pladienolide B

445493-23-2sc-391691
sc-391691B
sc-391691A
sc-391691C
sc-391691D
sc-391691E
0.5 mg
10 mg
20 mg
50 mg
100 mg
5 mg
$299.00
$5699.00
$11099.00
$25500.00
$66300.00
$2875.00
63
(2)

A splicing inhibitor that could indirectly influence MED7 function by affecting mRNA maturation and the transcription process.

Thiolutin

87-11-6sc-200387
sc-200387A
1 mg
5 mg
$101.00
$406.00
1
(2)

An RNA polymerase inhibitor with antibiotic and anti-inflammatory properties, potentially affecting MED7 activity by hindering transcription.